A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study
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ORIGINAL ARTICLE
BODY CONTOURING
A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study Antonio Scarano5 • Andrea Sbarbati1 • Roberto Amore2 • Eugenio Luigi Iorio3 Giuseppe Ferraro4 • Domenico Amuso1
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Received: 25 April 2020 / Accepted: 30 June 2020 The Author(s) 2020
Abstract Background Localized adiposity (AL) is the accumulation of subcutaneous adipose tissue, placed in definite anatomic areas, building up an alteration of the body silhouette. The aim of the present clinical and histological study is to assess the effectiveness of an injectable solution containing sodium salt of ascorbic acid 0.24% and surfactant agent at 0.020% ascorbyl-palmitate (SAP) for treating local adiposity. Methods Eighty healthy female adult patients were selected, suffering from local adiposity in the abdominal region. The patients underwent a cycle of 6 sessions, with biweekly treatments, without the addition of any active ingredient. Direct infiltration of pharmacologically active SAP solutions into the adipose tissue with a long needle, very similar to the needles used for spinal anesthesia, was performed. This procedure is quick and painless (does not require any anesthesia) with moderate infiltration speed.
Results All the patients treated showed good results with good satisfaction of the circumferential reductions. Before treatment: Waist (cm) 78.8 ± 10.6 and hip 93.6 ± 9.0 with WHR 0.84 ± 0.07. After treatment: Waist (cm) 70.8 ± 9.6 and hip 92.6 ± 8.0 with WHR 0.76 ± 0.06. Indeed, signs of adipocyte apoptosis were observed in subcutaneous skin after injection of SAP. Conclusion The results showed in the present study suggest that the SAP utilized induces apoptosis of adipocytes and could be of use as a safe and effective method with which to eliminate subcutaneous abdominal fat. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
& Antonio Scarano [email protected]
2
Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, School of Medicine, University of Verona, Verona, Italy
3
Master course in Aesthetic Medicine, Department of Medical, Oral and Biotechnological Sciences, University of ChietiPescara, Chieti, Pescara, Italy
4
Department of Plastic, Reconstructive and Aesthetic Surgery, Universita` degli Studi della Campania Luigi Vanvitelli, Naples, Italy
5
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Andrea Sbarbati [email protected] Roberto Amore [email protected]
Keywords Local adiposity Body contouring Lipolysis injection Ascorbic acid Ascorbyl-palmitate
Eugenio Luigi Iorio [email protected] Giuseppe Ferraro [email protected] Domenico Amuso d.amuso.estetica@gmail.
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