A Ni(II)-Containing Complex: Treatment Activity on Chronic Congestive Heart Failure via Reducing Inflammatory Response i
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ORIGINAL PAPER
A Ni(II)-Containing Complex: Treatment Activity on Chronic Congestive Heart Failure via Reducing Inflammatory Response in Cardiomyocytes Shu Xu1 • Dengshun Tao1 Received: 30 September 2020 / Accepted: 3 November 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Reaction of Ni(NO3)2 with KSCN and 1,3,5-tris(triazol-1-ylmethyl)-2,4,6-trimethylbenzene (TTTMB) leads to the formation of a new 3D Ni(II) coordination polymer {[Ni3(TTTMB)4(SCN)6]3.5H2O}n (1). Furthermore, the treatment activity of the compound on the inflammatory response during chronic congestive heart failure (CHF) was detected and the mechanism was explored. Firstly, the content of the inflammatory cytokines, such as Interleukin-1b (IL-1b) and tumor necrosis factor-a (TNF-a) released by cardiomyocytes was measured, and then the relative expression level of the NF-jB signal transduction was detected with real time RT-PCR. According to the data of molecular docking and post software evaluation, the functional groups of ligands may bind to NF-jB, thus providing a regulatory mechanism for ligands. Keywords Coordination polymer Congestive heart failure Molecular docking
Introduction In the past years, the chronic congestive heart failure (CHF) has got more and more attention from the researchers all over the world. CHF has been one of the most common disease in the clinic treatment, especially in the old [1, 2]. During aging, the deterioration of cardiac structure and function would lead to the increased susceptibility to heart failure. CHF is a common kind of heart failure. During the progression of CHF, there is usually combined with an increased inflammatory level in the myocardial tissue, leading to the over releasing of inflammatory cytokines [3, 4]. Thus, the new candidate that could significantly reduce the inflammatory was urgently needed, which will help us to reveal novel pathological and cardioprotective pathways. Structure and design of metal-involved supramolecular architectures based on crystal engineering are currently of interest in the field of supramolecular chemistry and coordination chemistry [5–8]. The increasing interest in this field is justified not only by their beautiful structures, & Dengshun Tao [email protected] 1
Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China
but also their potential applications in luminescence, catalysis and biochemistry, particularly in modern medicinal chemistry [9–12]. Among the series of compounds fabricated, the functional complexes attract great attention due to the potential drug value applications. The nitrogencontaining heterocyclic ligands are widely used in the rational design and controlled synthesis of these multifunctional complexes with promising bioactivity because of their abundant coordination modes and functional properties, as well as hydrogen-bonding donors and acceptors under solution conditions [13, 14]. Multidentate compl
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