A novel PET scanner with semiconductor detectors may improve diagnostic accuracy in the metastatic survey of head and ne
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ORIGINAL ARTICLE
A novel PET scanner with semiconductor detectors may improve diagnostic accuracy in the metastatic survey of head and neck cancer patients Toshiki Takei • Tohru Shiga • Yuichi Morimoto • Wataru Takeuchi • Kikuo Umegaki • Kazuki Matsuzaki • Shozo Okamoto • Keiichi Magota Toshihiro Hara • Satoshi Fukuda • Nagara Tamaki
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Received: 7 November 2011 / Accepted: 6 September 2012 / Published online: 3 November 2012 Ó The Japanese Society of Nuclear Medicine 2012
Abstract Objectives Our research group developed new PET scanner with semiconductor detectors for high spatial resolution with low scatter noise. On head and neck cancer (HNC) surgery, FDG-PET may often provide false-positive findings in cervical node involvements. Accordingly, we assessed diagnostic accuracy using this new scanner in the HNC patients as compared with the conventional lutetium oxyorthosilicate (LSO) PET. Methods We prospectively studied FDG imaging in 35 HNC patients by both semiconductor PET and LSO-PET. At 60 min after 18F-FDG injection, two PET scans were obtained using both scanners consecutively and in random order. Two nuclear medicine specialists scored FDG abnormalities using 5 point scale system for receiver operating characteristic (ROC) curve analysis. Results 63 suspected of metastatic or recurrent lesions were evaluated and correlated by the final confirmation by pathological findings or clinical courses (malignant T. Takei T. Shiga (&) S. Okamoto K. Magota N. Tamaki Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita15 Nishi7, Kita-ku, Sapporo 060-8638, Japan e-mail: [email protected] Y. Morimoto W. Takeuchi K. Matsuzaki Central Research Laboratory, Hitachi Ltd, Hitachi, Ibaraki, Japan K. Umegaki Department of Molecular Imaging, Graduate School of Hokkaido University, Sapporo, Japan T. Hara S. Fukuda Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
26/benign 37). Semiconductor PET showed sensitivity of 92.3 % (24/26), specificity of 51.4 % (19/37), and accuracy of 68.2 % (43/63), while LSO-PET showed sensitivity of 84.6 % (22/26), specificity of 16.2 %(6/37), and accuracy of 44.4 % (28/63), respectively. Especially, semiconductor PET accurately diagnosed as true negative in the 13 of 14 lesions only detected by LSO-PET. ROC analyses revealed the diagnostic superiority of semiconductor PET from location of- and area under curve particularly in the study of small (B10 mm) lesions. Conclusion A new novel semiconductor PET scanner can increase diagnostic accuracy with reduction in false positive findings in the HNC patients mainly due to higher spatial resolution and lower noise than the LSO-PET. This new technology can lead to more accurate diagnosis and the more optimal therapeutic tactics in head and neck surgery. Keywords Semiconductor scanner PET Head and neck cancer
Introduction Our research group developed new PET scanner with cadmium telluride (CdTe) semiconductor detectors [1–3]. C
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