Nucleophosmin 1 overexpression correlates with 18 F-FDG PET/CT metabolic parameters and improves diagnostic accuracy in
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ORIGINAL ARTICLE
Nucleophosmin 1 overexpression correlates with 18F-FDG PET/CT metabolic parameters and improves diagnostic accuracy in patients with lung adenocarcinoma Lu-Meng Zhou 1,2 & Ling-Ling Yuan 3 & Yan Gao 1 & Xu-Sheng Liu 1 & Qin Dai 4 & Jian-Wei Yang 2 & Zhi-Jun Pei 1,2,5,6 Received: 11 February 2020 / Accepted: 18 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose This study investigated the correlation of nucleophosmin 1 (NPM1) expression with 18F-fluorodeoxyglucose (18FFDG) positron emission tomography/computerised tomography scan (PET/CT)-related parameters and compared the diagnostic value of NPM1 with that of the positive biomarker TTF1 in lung adenocarcinoma patients. Methods Forty-six lung adenocarcinoma patients who underwent 18F-FDG PET/CT before pulmonary surgery were retrospectively analysed. Metabolic parameters including SUVmax, SUVmean, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were calculated from 18F-FDG PET imaging data. The expression levels of NPM1 and TTF1 were assessed using The Cancer Genome Atlas (TCGA) database and immunohistochemistry of tumour tissues and adjacent normal lung tissues. We examined the association between the frequency of NPM1 and TTF1 expression and the metabolic parameters. Results Lung adenocarcinoma samples expressed higher levels of NPM1 than adjacent normal lung epithelial tissues. NPM1 showed higher specificity and sensitivity for lung adenocarcinoma compared with TTF1 (p < 0.001). SUVmax, SUVmean and TLG correlated with NPM1 expression (p < 0.001). MTV was inversely correlated with TTF1 (p < 0.01). SUVmax was the primary predictor of NPM1 expression by lung adenocarcinoma (p < 0.01). A cutoff value for the SUVmax of 3.93 allowed 90.9% sensitivity and 84.6% specificity for predicting NPM1 overexpression in lung adenocarcinoma. Conclusion NPM1 overexpression correlated with 18F-FDG PET/CT metabolic parameters and improved diagnostic accuracy in lung adenocarcinoma. SUVmax on 18F-FDG PET/CT may estimate NPM1 expression for targeted therapy of lung adenocarcinoma. Keywords Lung adenocarcinoma . SUVmax . PET/CT . Thyroid transcription factor 1 . Nucleophosmin 1
Lu-Meng Zhou and Ling-Ling Yuan contributed equally to this work.
Introduction
This article is part of the Topical Collection on Oncology - Chest * Zhi-Jun Pei [email protected] 1
Department of Nuclear Medicine and Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China
2
Postgraduate Training Basement of Jinzhou Medical University, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China
3
Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China
4
Department of Eye center, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China
5
Hubei Key Laboratory of WudangLocal Chinese Medicine Research, Shiyan, Hubei, China
6
Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, Hubei, China
Lung cancer is the most co
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