A radial histogenetic model of the mouse pallial amygdala
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ORIGINAL ARTICLE
A radial histogenetic model of the mouse pallial amygdala Elena Garcia‑Calero1 · Margaret Martínez‑de‑la‑Torre1 · Luis Puelles1 Received: 20 December 2019 / Accepted: 5 June 2020 © The Author(s) 2020
Abstract Conventional anatomic models of the rodent (mammalian) amygdala are based on section planes oblique to its intrinsic radial glial organization. As a result, we still lack a model of amygdalar histogenesis in terms of radial units (progenitor domains and related radial migration and layering patterns). A radial model of the mouse pallial amygdala is first offered here, based on three logical steps: (1) analysis of amygdalar radial structure in variously discriminative genoarchitectonic material, using an optimal ad hoc section plane; (2) testing preliminary models with experiments labelling at the brain surface single packets of radial glia processes, to be followed into the ventricular surface across intervening predicted elements; (3) selection of 81 differential amygdalar gene markers and checking planar and radial aspects of their distribution across the model elements. This approach shows that subtle changes to the conventional schema of the amygdala allow a radial histogenetic model to be recognized, which is consistent with molecularly coded differential identities of its units and strata. It is expected that this model will help both causal studies of amygdalar developmental patterning and comparative evolutionary studies. It also may have potential impact on hodological and functional studies. Keywords Histogenesis · Radial migration · Stratification · Amygdalar pallium · Amygdalar structure · Amygdalar nuclei Abbreviations 2 Layer 2 3 Layer 3 4 Layer 4 A Amygdala AA Anterior amygdala ac Anterior commissure ACo Anterior cortical nucleus AHi Amygdalo-hippocampal area AHiCL Amygdalo-hippocampal area, caudolateral part AHiRL Amygdalo-hippocampal area, rostrolateral part AHiRM Amygdalo-hippocampal area, rostromedial part AI Insular cortex, agranular part Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00429-020-02097-4) contains supplementary material, which is available to authorized users. * Elena Garcia‑Calero [email protected] 1
Department of Human Anatomy, School of Medicine and IMIB‑Arrixaca Institute, University of Murcia, 30120 Murcia, Spain
ant Anterior radial unit AOS Amygdalo-olfactory stream APir Amygdalo-piriform area ASt Amygdalo-striatal transition area Au1 Auditory cortex BAOT Bed nucleus of the accessory olfactory tract bas Basal radial unit BEC Bed nucleus of the external capsule bl Basolateral radial subunit BLA Anterior basolateral nucleus BLI Intermediate basolateral nucleus BLP Posterior basolateral nucleus BMA Anterior basomedial nucleus bml Basomedio-lateral subunit bmm Basomedio-medial subunit BMP Posterior basomedial nucleus BMIL Lateral intermediate basomedial nucleus BMIM Medial intermediate basomedial nucleus BMPL Lateral posterior basomedial nucleus BMPM Medial posterior b
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