Mouse as a Model Organism From Animals to Cells
Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Su
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Cord Brakebusch · Taina Pihlajaniemi Editors
Mouse as a Model Organism From Animals to Cells
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Editors Cord Brakebusch University of Copenhagen Institute of Biomedicine, BRIC Ole Maaloes Vej 5 DK-2200 Copenhagen Denmark [email protected]
Taina Pihlajaniemi Oulu Center for Cell-Matrix Research FIN90014 Oulu Finland [email protected]
ISBN 978-94-007-0749-8 e-ISBN 978-94-007-0750-4 DOI 10.1007/978-94-007-0750-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011925376 © Springer Science+Business Media B.V. 2011 All illustrations are published with the kind permission of © Emilia Stasiak - Fotolia.com No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The importance of mice as model organism has continuously increased throughout the last decades due to the widespread use of genetically modified mice. These mice significantly increased our understanding of the function of specific genes in a living mammalian organism during development and in disease. Ongoing efforts to create knockouts and conditional knockouts of all mouse genes by high-throughput gene targeting and phenotyping are expected to further boost the use of mice in biomedical research. In June 2009, a symposium on “Mouse as a Model Organism – From Animals to Cells” was held in Rovaniemi, Finland, trying to give an overview about recent developments and future directions in the filed. This conference, organized by the “Nordish Infrastructure for Mouse Models” (www.norimm.org) and supported by NordForsk, brought together distinguished scientists from all over the world to discuss these topics together with students from many places in Europe in the immediate vicinity of the polar circle. Great research, the special atmosphere of Finnish Lapland in late spring with endless days and midnight sun, and not the least a meeting with Santa Claus himself in the nearby Santa Claus Village made the symposium a very unique experience. Out of that spirit and at the last day of the conference, the idea was born to combine review articles on different topics presented at that conference in a book. The response was very positive and the result can be seen on the following pages. The first four chapters cover general aspects of generation and phenotyping of genetically modified mice, including the use of genomic insulators in transgenic constructs, the running of a “Mouse Clinic” for high-throughput phenotyping, the effects of genetic background and environment on the phenotype of mutant mice, and the requirements for a phenotyping database. The next chap
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