A Review on Schiff Base Fluorescent Chemosensors for Cell Imaging Applications
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REVIEW
A Review on Schiff Base Fluorescent Chemosensors for Cell Imaging Applications Duraisamy Udhayakumari 1
&
V. Inbaraj 1
Received: 28 April 2020 / Accepted: 3 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Fluorescent determinations of analytes have proven to be a powerful method due to their simplicity, low cost, detection limit, rapid photoluminescence response, and applicability to bioimaging. Fluorescence imaging as a powerful tool for monitoring biomolecules within the living systems. Schiff base has been extensively used as strongly absorbing and colorful chromophores in the design of chemosensors. In recent years, Schiff base based fluorescent probes have been developed for the detection of various toxic analytes and imaging of various analytes in biological systems. This review gives an overview of the important fluorescent sensors which are based on Schiff base, their approaches for molecular recognition, and their potential application in bioimaging studies. Keywords Schiff base . Analytes . Fluorescence . Detection . Bioimaging
Introduction A challenge for versatile detection of toxic analytes in the environment, biological organs and tissues have been resolving by enhancing the interest in developing fluorescent probes [1–5]. Most of the toxic ions playing an important role in a variety of industrial operations such as food industry, pharmaceutical, paper, textile industry, refinery, water treatment, manufacturing of batteries and electronic field [6–10]. At the same time, toxic analytes are associated with severe neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and Wilson’s disease to the human body. Even the trace level distribution of these elements in living organisms can shift the character of enzyme catalysis, gene expression, protein sequence, DNA synthesis, reproductive process and immune function [11–15]. On the basis of consequences and speedy recovery from the above-mentioned disease, there is a greater demand to focus study on a fast detecting device for these toxic ions.
* Duraisamy Udhayakumari [email protected] 1
Department of Chemistry, Rajalakshmi Engineering College, Chennai 602105, India
Fluorescence technology is used by scientists from many disciplines such as biology, materials science, and biomedical sciences. The fluorescence measurement is usually versatile, very sensitive, low detection limit, and offers a submicromolar estimation of guest species [16–20]. In fluorogenic chemosensors, the interaction between the binding site and the guest moiety shows the changes in the fluorescence behavior of the signaling unit. The image processing technology was extensively improved from the year the 1960s onwards and there has been dramatic growth in the use of fluorescence for cellular and molecular imaging that can be seen today in almost every field. The imaging technique is widely used as biomarkers for disease identification, progress, and treatment responses. F
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