A Simple-to-Use Score for Identifying Individuals at High Risk of Denosumab-Associated Hypocalcemia in Postmenopausal Os
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ORIGINAL RESEARCH
A Simple‑to‑Use Score for Identifying Individuals at High Risk of Denosumab‑Associated Hypocalcemia in Postmenopausal Osteoporosis: A Real‑World Cohort Study Kyoung Jin Kim1,2 · Namki Hong1 · Seunghyun Lee1 · Miryung Kim3 · Yumie Rhee1 Received: 5 June 2020 / Accepted: 1 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Since denosumab-associated hypocalcemia occurs infrequently, data on its incidence and risk factors are limited. We aimed to evaluate risk factors and develop a useful score for identifying individuals at risk of denosumab-associated hypocalcemia. In this retrospective cohort, 790 consecutive female patients who received 60 mg denosumab at least once between 2016 and 2017 were analyzed. Based on biochemical records from a large-scale single-center, mild and moderate hypocalcemia were defined as albumin-corrected calcium (cCa) levels
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