A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan
- PDF / 972,449 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 121 Downloads / 166 Views
ORIGINAL ARTICLE
A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan Yu-Mei Kang 1,2,3 & Shih-Chieh Lin 1,4 & Yi-Yen Lee 1,5 & Feng-Chi Chang 1,6 & Muh-Lii Liang 1,5 & Hsin-Hung Chen 1,5 & Tai-Tong Wong 1,5 & Yi-Wei Chen 1,2 Received: 31 December 2019 / Accepted: 8 February 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose A basal ganglia (BG) germinoma is a rare tumor, and the optimal treatment remains unknown. We evaluated the clinical outcomes of treatment of BG germinoma in pediatric patients in Taiwan. Methods We retrospectively reviewed the medical records of 34 children with BG germinoma who were treated with radiotherapy (RT) at Taipei Veterans General Hospital between 1989 and 2016. The median follow-up time is 8.3 years (1.8–25.2 years). Survival was analyzed using the Kaplan–Meier estimate. Univariate Cox proportional-hazards models were used to identify the potential risk factors. Results Only four patients (11.8%) experienced recurrence and all successfully underwent salvage therapy. One patient (2.97%) died due to suspected radiotherapy (RT)-related sarcoma in the scalp. The 2-, 3-, and 5-year DFS rates were 91.2%, 88.2%, and 79.4%, respectively; the 2-, 3-, and 5-year OS rates were 97.1%, 94.1%, and 82.4%, respectively. Focal RT showed low DFS in the Kaplan–Meier survival curves (P = .028) compared with non-focal RT (whole ventricle, whole brain, or cranial spinal area). In the univariate Cox proportional-hazards model, there was a significant difference in DFS between focal and non-focal RT (P = .03). There is no difference in DFS and OS between BG germinoma patients and non-BG germinoma patients. Conclusions We found an excellent DFS and OS in pediatric patients with BG germinoma treated with RT. Whole ventricle irradiation is recommended for good tumor control and low treatment-related toxicity. BG germinoma patients showed similar treatment results as germinoma patients in other common sites. Keywords Basal ganglia . Germinoma . Pediatric . Radiotherapy . Chemotherapy . Whole ventricular irradiation
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00381-020-04543-4) contains supplementary material, which is available to authorized users. * Yi-Wei Chen [email protected] 1
Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan
2
Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
3
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
4
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
5
Division of Pediatric Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
6
Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
Introduction Intracranial germinomas (IGs) are a rare type of tumor, which account for only 0.22–3% [15, 20] of all intracranial tumors in children and adolescents.
Data Loading...
