Absorption of Orally Administered Enzymes
This book is a compilation of papers that arose from a multidisciplinary workshop held at the Walter-Straub-Institute for Pharmacology and Toxicology in Munich in September 1993 to review the current state fo knowledge relating to the oral administration
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K.-J. Steffens
(Eds.)
Absorption of Orally Administered Enzymes With 60 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Prof. Dr. MICHAEL L.G. GARDNER University of Bradford Department of Biomedical Sciences Bradford BD7 lDP, West Yorkshire United Kingdom Prof. Dr. KLAUS-JORGEN STEFFENS Rheinische Friedrich-Wilhelms-UniversiUit Pharmazeutisches Institut Pharmazeutische Technologie An der Immenburg 4 D-53121 Bonn, FRG
ISBN-13:978-3-642-79513-8 DOl: 10.1007/978-3-642-79511-4
e-ISBN-13:978-3-642-79511-4
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Preface
Although there has been much interest over many years in the use of orally administered proteolytic enzymes, especially trypsin and bromelain, as possible therapeutic agents, there is considerable controversy about the underlying physiological rationale for such use, about the mechanisms of their actions at target tissues, and about their efficacy against disease. In particular, the possibility of such large proteins being absorbed across the gastrointestinal tract in native and active form has been viewed with sceptism by many scientisists and practitioners. However, over the last decade there has been considerable expansion of knowledge about absorption of intact proteins and about the routes and mechanisms involved; also, it must be noted that proteolytic enzymes are inherently more resistent to enzymic digestion than many other proteins. Indeed, there is a long-standing hypothesis that trypsin normally undergoes an entero-pancreatic recirculation process akin to the entero-hepatic recirculation that is accepted for bile salts, and it is even possible that this is part of a normal physiological homeostatic mechanism. Hence, absorption of intact enzymes in large enough amounts to have biological
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