Acetyl- l -carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats
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ORIGINAL PAPER
Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats Thangaraj Annadurai & Shankaravadivelu Vigneshwari & Rajendran Thirukumaran & Philip A. Thomas & Pitchairaj Geraldine
Received: 11 December 2010 / Accepted: 19 April 2011 / Published online: 27 May 2011 # University of Navarra 2011
Abstract Acetyl- L-carnitine (ALCAR) has been shown to prevent experimental selenite cataractogenesis, a manifestation of oxidative stress, but little is known about its potential in other settings of oxidative stress. The present study was based on the hypothesis that ALCAR prevents carbon tetrachloride (CCl4)-induced oxidative stress in vital tissues. Male albino Wistar rats were divided into three groups, each of six rats. Group I (control) rats received only vehicle (1 ml/kg b.w.) for 4 days; Group II (CCl4exposed, untreated) rats received CCl4 (2 ml/kg b.w.) on the second and third days and vehicle on the first and fourth days; Group III (CCl4-exposed, ALCARtreated) rats received ALCAR (200 mg/kg b.w.) for 4 days and CCl4 on the second and third days. All administrations were made intraperitoneally. After the experimental period, significantly (P
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