Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease
Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, internationally recognized experts review AJ bio
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Tony Harris Editor
Adherens Junctions: From Molecular Mechanisms to Tissue Development and Disease
Subcellular Biochemistry
Series Editor Robin Harris
For further volumes: http://www.springer.com/series/6515
Tony Harris Editor
Adherens Junctions: From Molecular Mechanisms to Tissue Development and Disease
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Editor Tony Harris Department of Cell and Systems Biology University of Toronto Toronto, ON Canada
ISSN 0306-0225 ISBN 978-94-007-4185-0 ISBN 978-94-007-4186-7 (eBook) DOI 10.1007/978-94-007-4186-7 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2012938445 Springer Science+Business Media Dordrecht 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 An Introduction to Adherens Junctions: From Molecular Mechanisms to Tissue Development and Disease ��������������������������������� 1 Tony J. C. Harris Part I How AJs Evolved 2 Evolution of the Cadherin–Catenin Complex �������������������������������������� 9 Hiroki Oda Part II How Cadherins and Catenins Interact to Assemble AJs 3 The Three-Dimensional Structure of the Cadherin–Catenin Complex �������������������������������������������������������� 39 Noboru Ishiyama and Mitsuhiko Ikura 4 Biophysics of Cadherin Adhesion ���������������������������������������������������������� 63 Deborah Leckband and Sanjeevi Sivasankar 5 Adherens Junction Assembly ����������������������������������������������������������������� 89 Sergey Troyanovsky Part III How AJs Interface with Other Cellular Machinery 6 The Cytoskeleton and Classical Cadherin Adhesions �������������������������� 111 Siew Ping Han and Alpha S. Yap 7 Immunoglobulin Superfamily Receptors and Adherens Junctions ���� 137 Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai 8 Signaling from the Adherens Junction �������������������������������������������������� 171 Abbye E. McEwen, David E. Escobar and Cara J. Gottardi V
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Contents
9 Adherens Junction Turnover: Regulating Adhesion Through Cadherin Endocytosis, Degradation, and Recycling ���������� 197 Andrew P. Kowalczyk and Benjamin A. Nanes Part IV How AJs Affect Cell Behaviour and Multicellular Development 10 Adherens Junctions During Cell Migration ��������������������������������������� 225 Sandrine Etienne-Manneville 11 Adherens Junctions and Cadherins in Drosophila Development ������ 251 Annalisa Letizia and Marta Llimargas 12 Adherens Junctions in C. elegans Embryonic Morphogenesis ��������� 279 Stephen T. Armenti and Jeremy Nance 13 Cadherin Fu
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