Adhesion in Leukocyte Homing and Differentiation
This volume of Current Topics in Microbiology and Immunology was planned in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held at the Basel Institute for Immunology in November 1992, and many of the work
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Editors
A. Capron, Lille . R.W. Compans, Atlanta/Georgia
M. Cooper, Birmingham/Alabama' H. Koprowski, Philadelphia . I. McConnell, Edinburgh . F. Melchers, Basel M. Oldstone, La Jolla/California . S. Olsnes, Oslo M. Potter, Bethesda/Maryland . H. Saedler, Cologne P. K. Vog!, Los Angeles' H. Wagner, Munich I. Wilson, La Jolla/California
Adhesion in Leukocyte Homing and Differentiation Edited by D. Dunon, C. R. Mackay and B.A. Imhof
With 37 Figures and 13 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
DOMINIQUE DUNON, Ph.D. CHARLES R. MACKAY, Ph.D. BEAT A. IMHOF, Ph.D.
Basel Institute for Immunology Grenzacherstr. 487 4005 Basel Switzerland
Cover illustration: Colonization of different organs (large spheres) by leukocytes (small spheres) is mediated by adhesion molecules. Leukocyte subsets can also undergo differentiation which is indicated by the colour changing to red. (Designed by Andre Traunecker, Basel Institute for Immunology.) Cover design: Harald Lopka, Jlvesheim ISSN 0070-217X ISBN-13:978-3-642-78255-8 e-ISBN-13:978-3-642-78253-4 001: 10.1007/978-3-642-78253-4 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broad-casting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.
© Springer-Verlag
Berlin Heidelberg 1993 Softcover reprint of the hardcover 15t edition 1993 Library of Congress Catalog Card Number 15-12910 The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement. that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained on this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.
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Preface
This volume of Current Topics in Microbiology and Immunology was planned in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held at the Basel Institute for Immunology in November 1992, and many of the workshop speakers have contributed to it. Cell adhesion is one of the most dynamic fields of biological research and presented in this book is the current knowledge on the structure and function of the major families of cell adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. Complex interactions between the members of these families mediate diverse adhesion functions,
