Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
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RESEARCH ARTICLE
Open Access
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study Caroline J. Bull1,2,3*† , Joshua A. Bell1,2†, Neil Murphy4, Eleanor Sanderson1,2, George Davey Smith1,2, Nicholas J. Timpson1,2, Barbara L. Banbury5, Demetrius Albanes6, Sonja I. Berndt6, Stéphane Bézieau7, D. Timothy Bishop8, Hermann Brenner9,10,11, Daniel D. Buchanan12,13,14, Andrea Burnett-Hartman15, Graham Casey16, Sergi Castellví-Bel17, Andrew T. Chan18,19,20,21, Jenny Chang-Claude22,23, Amanda J. Cross24, Albert de la Chapelle25, Jane C. Figueiredo26,27, Steven J. Gallinger28, Susan M. Gapstur29, Graham G. Giles30,31,32, Stephen B. Gruber33, Andrea Gsur34, Jochen Hampe35, Heather Hampel36, Tabitha A. Harrison5, Michael Hoffmeister9, Li Hsu5,37, Wen-Yi Huang6, Jeroen R. Huyghe5, Mark A. Jenkins31, Corinne E. Joshu38, Temitope O. Keku39, Tilman Kühn22, Sun-Seog Kweon40,41, Loic Le Marchand42, Christopher I. Li5, Li Li43, Annika Lindblom44,45, Vicente Martín46,47, Anne M. May48, Roger L. Milne30,31,32, Victor Moreno46,49,50,51, Polly A. Newcomb5,52, Kenneth Offit53,54, Shuji Ogino55,56,57,58, Amanda I. Phipps5,59, Elizabeth A. Platz38, John D. Potter5,60,61,62, Conghui Qu5, J. Ramón Quirós63, Gad Rennert64,65,66, Elio Riboli67, Lori C. Sakoda5,68, Clemens Schafmayer69, Robert E. Schoen70, Martha L. Slattery71, Catherine M. Tangen72, Kostas K. Tsilidis67,73, Cornelia M. Ulrich74, Fränzel J. B. van Duijnhoven75, Bethany van Guelpen76,77, Kala Visvanathan38, Pavel Vodicka78,79,80, Ludmila Vodickova78,79,80, Hansong Wang42, Emily White5,81, Alicja Wolk82, Michael O. Woods83, Anna H. Wu84, Peter T. Campbell85, Wei Zheng86, Ulrike Peters5, Emma E. Vincent1,2,3† and Marc J. Gunter4†
Abstract Background: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. (Continued on next page)
* Correspondence: [email protected] † Caroline J. Bull and Joshua A. Bell are joint first authors. Emma E. Vincent and Marc J. Gunter are joint last authors. 1 MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Bristol, UK 2 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and yo
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