Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance
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(2020) 11:110
REVIEW
Open Access
Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance Massimo Bionaz1* , Einar Vargas-Bello-Pérez2 and Sebastiano Busato1
Abstract High producing dairy cows generally receive in the diet up to 5–6% of fat. This is a relatively low amount of fat in the diet compared to diets in monogastrics; however, dietary fat is important for dairy cows as demonstrated by the benefits of supplementing cows with various fatty acids (FA). Several FA are highly bioactive, especially by affecting the transcriptome; thus, they have nutrigenomic effects. In the present review, we provide an up-to-date understanding of the utilization of FA by dairy cows including the main processes affecting FA in the rumen, molecular aspects of the absorption of FA by the gut, synthesis, secretion, and utilization of chylomicrons; uptake and metabolism of FA by peripheral tissues, with a main emphasis on the liver, and main transcription factors regulated by FA. Most of the advances in FA utilization by rumen microorganisms and intestinal absorption of FA in dairy cows were made before the end of the last century with little information generated afterwards. However, large advances on the molecular aspects of intestinal absorption and cellular uptake of FA were made on monogastric species in the last 20 years. We provide a model of FA utilization in dairy cows by using information generated in monogastrics and enriching it with data produced in dairy cows. We also reviewed the latest studies on the effects of dietary FA on milk yield, milk fatty acid composition, reproduction, and health in dairy cows. The reviewed data revealed a complex picture with the FA being active in each step of the way, starting from influencing rumen microbiota, regulating intestinal absorption, and affecting cellular uptake and utilization by peripheral tissues, making prediction on in vivo nutrigenomic effects of FA challenging. Keywords: Absorption, Dairy cow, Dietary fatty acids, Intestine, Liver, Metabolism, Performance, Transcription factors, Transport
Introduction Important advances in the understanding of overall lipid digestion, absorption, and metabolism in dairy cows has been made between 1950 to 1990; afterwards, due to technological advances, a larger emphasis was placed on determining the molecular aspects of those processed. Furthermore, before the 1990’s, the effect fatty acids (FA) on transcription of genes was virtually unknown. * Correspondence: [email protected] 1 Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA Full list of author information is available at the end of the article
Discovery of transcription factors (TF) that sense the presence of lipids, especially FA, and the advances in the understanding of biological effects of FA in many pathways and functions in cells, have provided a great window into the biological roles of FA. Borrowing methods and knowledge obtained from monogastric species, especially model o
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