Ageing: Lessons from C. elegans
This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basi
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Anders Olsen Matthew S. Gill Editors
Ageing: Lessons from C. elegans
Healthy Ageing and Longevity Volume 5
Series editor Suresh I.S. Rattan, Aarhus, Denmark
More information about this series at http://www.springer.com/series/13277
Anders Olsen • Matthew S. Gill Editors
Ageing: Lessons from C. elegans
Editors Anders Olsen Department of Molecular Biology and Genetics Aarhus University Aarhus, Denmark
Matthew S. Gill Department of Metabolism & Aging The Scripps Research Institute Jupiter, FL, USA
ISSN 2199-9007 ISSN 2199-9015 (electronic) Healthy Ageing and Longevity ISBN 978-3-319-44701-8 ISBN 978-3-319-44703-2 (eBook) DOI 10.1007/978-3-319-44703-2 Library of Congress Control Number: 2016957399 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Introduction.............................................................................................. 1 Anders Olsen and Matthew S. Gill 2 Effects of Ageing on the Basic Biology and Anatomy of C. elegans.............................................................................................. 9 Laura A. Herndon, Catherine A. Wolkow, Monica Driscoll, and David H. Hall 3 Dauer Formation and Ageing................................................................. 41 Pedro Reis-Rodrigues, Kailiang Jia, and Matthew S. Gill 4 Longevity Regulation by Insulin/IGF-1 Signalling............................... 63 Seon Woo A. An, Murat Artan, Sangsoon Park, Ozlem Altintas, and Seung-Jae V. Lee 5 Mitochondrial Longevity Pathways....................................................... 83 Alfonso Schiavi and Natascia Ventura 6 Influences of Germline Cells on Organismal Lifespan and Healthspan............................................
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