Aging attenuates the ovarian circadian rhythm
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REPRODUCTIVE PHYSIOLOGY AND DISEASE
Aging attenuates the ovarian circadian rhythm Ziru Jiang 1,2 & Kexin Zou 1,2 & Xia Liu 1,2 & Hangchao Gu 1,2 & Yicong Meng 1,2 & Jing Lin 1,2 & Weihui Shi 1,2 & Chuanjin Yu 1,2 & Li Jin 1,2 & Li Wang 1,2 & Xinmei Liu 1,2 & Jianzhong Sheng 3 & Hefeng Huang 1,2 & Guolian Ding 1,2 Received: 4 October 2019 / Accepted: 3 April 2020 # The Author(s) 2020
Abstract Objective To study the effect of aging on ovarian circadian rhythm. Design Human and animal study. Setting University hospital and research laboratory. Patients/animals Human granulosa cells were obtained by follicular aspiration from women undergoing in vitro fertilization (IVF), and ovarian and liver tissues were obtained from female C57BL/6 mice. Intervention(s) None. Main outcome measure(s) Expression of circadian genes in young and older human granulosa cells and circadian rhythm in ovaries and livers of young and older mice. Result(s) All examined circadian clock genes in human granulosa cells showed a downward trend in expression with aging, and their mRNA expression levels were negatively correlated with age (P < 0.05). Older patients (≥ 40 years of age) had significantly reduced serum anti-Müllerian hormone (AMH) levels. Except for Rev-erbα, all other examined circadian clock genes were positively correlated with the level of AMH (P < 0.05). The circadian rhythm in the ovaries of older mice (8 months) was changed significantly relative to that in ovaries of young mice (12 weeks), although the circadian rhythm in the livers of older mice was basically consistent with that of young mice. Conclusion(s) Lower ovarian reserve in older women is partially due to ovarian circadian dysrhythmia as a result of aging. Keywords Circadian rhythm . Ovary . Age . Fertility
Introduction Ziru Jiang and Kexin Zou contributed equally to this work. Summary sentence: Subfertility in older women is partially due to ovarian circadian dysrhythmia as a result of aging. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10815-020-01943-y) contains supplementary material, which is available to authorized users. * Hefeng Huang [email protected] * Guolian Ding [email protected] 1
The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, 910 Hengshan Road, Shanghai 200030, China
2
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China
3
Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China
The circadian clock is also known as the physiological clock. In mammals, the circadian clock system is composed of coordinated and synchronized cell and tissue clocks, including two main parts: the central clock located in the suprachiasmatic nucleus (SCN) of the basal hypothalamus and the peripheral clock in the various tissues of the body. Therefore, the internal circadian clock organization is broadly defined as a coordinated and synchronized central and peripheral clock rhythm [1]. D
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