Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer
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ORIGINAL ARTICLE
Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer Keigo Okamoto1 · Kazuki Hayashi1 · Ryosuke Kaku1 · Yo Kawaguchi1 · Yasuhiko Oshio1 · Jun Hanaoka1 Received: 6 May 2020 / Accepted: 11 August 2020 © The Japanese Association for Thoracic Surgery 2020
Abstract Objective Fractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung surgery. However, its effects in the late postoperative period are unknown. The aim of this prospective study was to clarify the impact of FeNO on postoperative lung function in patients with lung cancer. Methods We measured preoperative FeNO using NIOX VERO® in patients with primary lung cancer. Patients were divided into two groups according to their potential airway inflammatory status: preoperative FeNO levels below 25 ppb (N group) and above 25 ppb (H group). They were evaluated by spirometry at 3 and 6 months after surgery during follow-up. The relationship between postoperative lung function and preoperative FeNO was evaluated. Results Between September 2017 and March 2019, 61 participants were enrolled. All of them underwent lobectomy as a curative surgery. There were no significant background variables between the two groups. Postoperative vital capacity (VC) and forced expiratory volume in 1 s (FEV1) in the H group achieved less predictive values than those in the N group, which were not significant. The postoperative VC and FEV1 from 3 to 6 months in the H group were significantly increased as compared to those in the N group (p
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