ALERT - Adverse Late Effects of Cancer Treatment Volume 1: General C

The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT – Adverse Late Effects of

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Philip Rubin Louis S. Constine Lawrence B. Marks Editors

ALERT – Adverse Late Effects of Cancer Treatment Volume 1: General Concepts and Specific Precepts

123

Medical Radiology Radiation Oncology

Series Editors Luther W. Brady Hans-Peter Heilmann Michael Molls Carsten Nieder

For further volumes: http://www.springer.com/series/4353

Associate Editors Zeljko Vujaskovic, Ph.D., Professor of Radiation Oncology, Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC, 27710, USA Kishan J. Pandya, MD, Professor Emeritus, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave, Box HH67, Rochester, NY, 14620, USA

Advisory Editors Yuhchyau Chen, MD, Ph.D., Department Chair and Richard Bell Professor, Director of Clinical Investigation, Department of Radiation Oncology, Professor in Oncology, James P. Wilmot Cancer Center, 601 Elmwood Ave, Box 647, Rochester, NY, 14642, USA Luis Felipe Fajardo, L-G, MD, Emeritus Professor of Pathology, Stanford University School of Medicine, 4190 Cherry Oaks Place, Palo Alto, CA, 94306, USA John Hansen, Ph.D., Professor of Neurobiology and Anatomy, and Associate Dean, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

Managing Editor Sisi Lisa Chen, Executive Coordinator of the Survivorship Advisory Committee, Editorial Assistant, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY, 14642, USA

Co-Managing Editor Liyi Xie, MD, Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA; Department of Radiation Oncology, Fudan University of Shanghai Cancer Center, Shanghai, China

Assistant Managing Editor Callise Wiley, Editorial Assistant to Dr. Philip Rubin, Oncoideas, Inc

Philip Rubin • Louis S. Constine Lawrence B. Marks Editors

ALERT – Adverse Late Effects of Cancer Treatment Volume 1: General Concepts and Specific Precepts

123

Editors Philip Rubin MD Professor and Chair Emeritus Department of Radiation Oncology Former Associate Director of the James. P. Wilmot Cancer Center, University of Rochester Medical Center Rochester, NY USA

Lawrence B. Marks MD, FASTRO Dr. Sidney K. Simon Distinguished Professor of Oncology Research, Professor and Chairman Department of Radiation Oncology University of North Carolina and Lineberger, Comprehensive Cancer Center Chapel Hill, NC USA

Louis S. Constine MD, FASTRO The Philip Rubin Professor of Radiation Oncology and Pediatrics, Vice Chair Department of Radiation Oncology, James P. Wilmot Cancer Center University of Rochester Medical Center Rochester, NY USA

ISSN 0942-5373 ISBN 978-3-540-72313-4 ISBN 978-3-540-72314-1 DOI 10.1007/978-3-540-72314-1

(eBook)

Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013930143  Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, b