Late and Long-Term Treatment-Related Effects and Survivorship for Head and Neck Cancer Patients

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Head and Neck Cancer (CP Rodriguez, Section Editor)

Late and Long-Term Treatment-Related Effects and Survivorship for Head and Neck Cancer Patients Marci Lee Nilsen, PhD, RN, CHPN1,2,* Michael A. Belsky, MS3 Nicole Scheff, PhD4 Jonas T. Johnson, MD2 Dan P. Zandberg, MD5 Heath Skinner, MD, PhD6 Robert Ferris, MD, PhD7 Address *,1 School of Nursing, Department of Acute and Tertiary Care, University of Pittsburgh, 318A Victoria Building, 3500 Victoria Street, Pittsburgh, PA, 15261, USA Email: [email protected] 2 School of Medicine, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA 3 School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA 4 School of Medicine, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA 5 Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA 6 School of Medicine, Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA 7 UPMC Hillman Cancer Center, Pittsburgh, PA, USA

* Springer Science+Business Media, LLC, part of Springer Nature 2020

This article is part of the Topical Collection on Head and Neck Cancer Keywords Head and neck cancer I Survivorship I Treatment effects I Toxicities

Opinion statement The demographics of head and neck cancer (HNC) survivors are changing, contributing to a growing number of survivors and a greater length of survivorship. Curative treatment involves intense multimodal therapy, which contributes to both short-term toxicities and long-term treatment-related effects. Delivering high-quality, relevant cancer survivorship care is a growing national priority. Various survivorship models and tools, such as survivorship care plans, have been utilized in an attempt to enhance care and optimize

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Curr. Treat. Options in Oncol.

(2020) 21:92

outcomes. However, an essential, yet understudied, component of high-quality survivorship care is the identification and management of late and long-term treatment-related effects. In this article, we will describe the current advancements in survivorship care as well as the research related to late and long-term treatment effects. While there is a growing body of literature that describes the prevalence of treatment-related effects and their impact on quality of life, more work is needed. Research that investigates the interplay of these complex treatment effects, the biological mechanisms that contribute to their variability, and interventions designed to mitigate them are desperately needed. While de-intensification offers the potential to alleviate these effects for future survivors, we need clinically meaningful assessment tools and therapies to provide the survivors we evaluate and treat daily. Targeted patient-reported outcomes and objective measures validated through clinical research are needed to help us systematically identify and treat late and long-term effects. In order to tailor and optimize the care we provide to our HNC survivors, we will need to leverage these tools as well as the expertise of