Alteration of Resting-state Functional Connectivity in the Sensorimotor Network in Patients with Thalamic Infarction
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ORIGINAL ARTICLE
Alteration of Resting-state Functional Connectivity in the Sensorimotor Network in Patients with Thalamic Infarction Miao He1 · Jiarui Song1 · Tianyou Luo2 · Kangcheng Wang3 · Yang Li1 · Fajin Lv2 · Li Chen1 Received: 5 September 2019 / Accepted: 9 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To explore changes in functional connectivity (FC) within the sensorimotor network (SMN) and the relationship between the SMN and bilateral thalamus in patients with thalamic infarction (TI) using resting state functional magnetic resonance imaging (rs-fMRI). Also determined was whether those measures are useful for monitoring the functional recovery of somatosensory deficits. Methods The study included 31 patients with TI presenting somatosensory dysfunction and 31 controls who underwent clinical assessments and MRI scanning at 6 months after a stroke. An independent component analysis was used to identify the SMN. The mean time courses of SMN activity were extracted for each subject, and FC with the bilateral thalamus was assessed. Differences in connectivity strength were compared between groups. Finally, we correlated the altered FC values with clinical data from patients with TI. Results Compared to controls, patients with TI showed decreases in FC within SMN in the ipsilesional posterior central gyrus (PCG) (Z-score = –4.581, cluster size = 171), but presented increased FC within the SMN in the ipsilesional supplementary motor area (SMA) (Z-score = 4.648, cluster size = 46). The FC values of the ipsilesional SMA correlated with the somatosensory function score of patients with TI (r = 0.426, P = 0.027). Increased FC was observed between the SMN and bilateral thalamus in patients with TI. The region exhibiting increased FC was adjacent to the lesion in the affected thalamus, while the area with increased FC overlapped the location of the lesion when the lesion was mirrored onto the unaffected thalamus. Conclusion The increased FC in the ipsilesional SMA and between the SMN and perilesional thalamus might reflect functional reorganization in patients with TI presenting somatosensory deficits.
Keywords Stroke · MRI · Cerebral plasticity · Somatosensory function · Reorganization
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00062-020-00966-3) contains supplementary material, which is available to authorized users. Li Chen
[email protected] 1
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, 637000 Nanchong, China
2
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
3
School of Psychology, Shandong Normal University, Jinan, China
The thalamus is part of the diencephalon, which forms numerous connections and transmits various types of information between the cerebral cortex and subcortical structures. Each nucleus of the thalamus connects specific cortical regions and deep nuclei in su
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