Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura
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(2020) 21:111
The Journal of Headache and Pain
RESEARCH ARTICLE
Open Access
Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura Heng-Le Wei1†, Jing Chen2†, Yu-Chen Chen3, Yu-Sheng Yu1, Xi Guo1, Gang-Ping Zhou1, Qing-Qing Zhou1, Zhen-Zhen He1, Lian Yang1, Xindao Yin3, Junrong Li2* and Hong Zhang1*
Abstract Background: Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functional connectivity in MwoA remain unclear. We aimed to explore the association between clinical characteristics and effective functional connectivity in SMN, in interictal patients who have MwoA. Methods: We used Rs-fMRI to acquire imaging data in 40 episodic patients with MwoA in the interictal phase and 34 healthy controls (HCs). Independent component analysis was used to profile the distribution of SMN and calculate the different SMN activity between the two groups. Subsequently, Granger causality analysis was used to analyze the effective functional connectivity between the SMN and other brain regions. Results: Compared to the HCs, MwoA patients showed higher activity in the bilateral postcentral gyri (PoCG), but lower activity in the left midcingulate cortex (MCC). Moreover, MwoA patients showed decreased effective functional connectivity from the SMN to left middle temporal gyrus, right putamen, left insula and bilateral precuneus, but increased effective functional connectivity to the right paracentral lobule. There was also significant effective functional connectivity from the primary visual cortex, right cuneus and right putamen to the SMN. In the interictal period, there was positive correlation between the activity of the right PoCG and the frequency of headache. The disease duration was positively correlated with abnormal effective functional connectivity from the left PoCG to right precuneus. In addition, the headache impact scores were negatively correlated with abnormal effective functional connectivity from the left MCC to right paracentral lobule, as well as from the right precuneus to left PoCG. Conclusions: These differential, resting-state functional activities of the SMN in episodic MwoA may contribute to the understanding of migraine-related intra- and internetwork imbalances associated with nociceptive regulation and chronification. Keywords: Magnetic resonance imaging, Migraine, Sensorimotor network, Effective functional connectivity
* Correspondence: [email protected]; [email protected] † Heng-Le Wei and Jing Chen contributed equally to this work. 2 Department of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, Jiangsu, China 1 Department of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, Jiangsu, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article
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