Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant
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ARTICLE
Altered hormonal and autonomic nerve responses to hypoand hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes Martin H. Lundqvist 1 & Kristina Almby 1 Maria J. Pereira 1 & Jan W. Eriksson 1
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Urban Wiklund 2
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Niclas Abrahamsson 1
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Prasad G. Kamble 1
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Received: 16 June 2020 / Accepted: 1 October 2020 # The Author(s) 2020
Abstract Aims/hypothesis Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine response to various glucose concentrations in overweight and insulin-resistant individuals compared with lean individuals. Methods Overweight/obese (HI, n = 15, BMI ≥27.0 kg/m2) and lean (LO, n = 15, BMI
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