Amenorrhea A Case-Based, Clinical Guide
Amenorrhea: A Case-Based Clinical Guide is a comprehensive review of the current knowledge regarding normal female reproductive physiology. Replete with interesting case vignettes and providing diagnostic algorithms and therapeutic strategies for amenorrh
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Series Editor P. Michael Conn, PhD Oregon Health & Science University Beaverton, OR
For other titles published in this series, go to www.springer.com/series/7680
Nanette F. Santoro Genevieve Neal-Perry ●
Editors
Amenorrhea A Case-Based, Clinical Guide
Editors Nanette F. Santoro Department of Obstetrics and Gynecology University of Colorado Denver School of Medicine Aurora, CO, USA [email protected]
Genevieve Neal-Perry Department of Obstetrics and Gynecology Division of Reproductive Endocrinology and Infertility Albert Einstein College of Medicine Bronx, NY, USA [email protected]
ISBN 978-1-60327-863-8 e-ISBN 978-1-60327-864-5 DOI 10.1007/978-1-60327-864-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010936295 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science + Business Media (www.springer.com)
Preface
Female reproductive success relies upon coordinated interactions among the hypothalamus, the pituitary, and the ovaries and the subsequent hormonal priming of the endometrium for implantation. The absence of oocyte fertilization or the failure of embryo implantation results in ovarian hormone withdrawal, the onset of menses, and the beginning of the next reproductive cycle. Failure of any single organ in the quartet to play its part can result in amenorrhea. Although amenorrhea is a common problem that affects up to 10% of reproductive aged women, there has not been a major textbook solely dedicated to this clinical problem for more than 20 years. The main purpose of this first edition of Amenorrhea: A Case-Based Clinical Guide was to organize a comprehensive review that updates clinicians on our current knowledge regarding normal female reproductive physiology and to discuss the pathophysiology, diagnostic algorithms, and therapeutic intervention for amenorrhea. With this principal goal, we have invited several world experts on female reproductive physiology to provide clinicians with highly practical information regarding the epidemiology and management of amenorrhea. To that end, the content of this textbook has been divided into three sections; the first section is composed of two chapters that provide a comprehensive updated review on our basic science and clinical knowledge
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