Neurodegenerative Disorders A Clinical Guide
This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice.Beginning with an overview o
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Neurodegenerative Disorders A Clinical Guide Second Edition
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Neurodegenerative Disorders
Orla Hardiman • Colin P. Doherty Editors
Marwa Elamin • Peter Bede Associate Editors
Neurodegenerative Disorders A Clinical Guide Second Edition
Editors Orla Hardiman Academic Unit of Neurology Trinity Biomedical Sciences Institute Dublin Ireland
Associate Editors Marwa Elamin Academic Unit of Neurology Trinity Biomedical Sciences Institute Dublin Ireland
Colin P. Doherty Academic Unit of Neurology Trinity Biomedical Sciences Institute Dublin Ireland
Peter Bede Academic Unit of Neurology Trinity Biomedical Sciences Institute Dublin Ireland
ISBN 978-3-319-23308-6 ISBN 978-3-319-23309-3 DOI 10.1007/978-3-319-23309-3
(eBook)
Library of Congress Control Number: 2015958656 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Contents
1
Common Themes in the Pathogenesis of Neurodegeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Marina A. Lynch, Orla Hardiman, Marwa Elamin, Janine Kirby, and Lewis P. Rowland
1
2
Imaging Biomarkers in Neurodegenerative Conditions. . . . . . Parameswaran Mahadeva Iyer, Colin P. Doherty, and Peter Bede
13
3
Role of Neuropsychology in Neurodegeneration . . . . . . . . . . . Marwa Elamin, Thomas H. Bak, Colin P. Doherty, Niall Pender, and Sharon Abrahams
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4
Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Damien Gallagher, Robert F. Coen, and Brian A. Lawlor
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5
Dementia and Cerebrovascular Disease. . . . . . . . . . . . . . . . . . . Joseph Harbison, Sean P. Kennelly, and Rose Anne Kenny
75
6
Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diana A. Olszewska, Stanley Fahn, Richard A. Wa
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