American Trypanosomiasis
American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite, Trypanosoma cruzi. Sixteen to eighteen million people are currently infected with this organism, and 45,000 deaths are attributed to the disease each year. Infection with T.
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World Class Parasites VOLUME 7
Volumes in the World Class Parasites book series are written for researchers, students and scholars who enjoy reading about excellent research on problems of global significance. Each volume focuses on a parasite, or group of parasites, that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense . The volumes are intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. They integrate vector, pathogen and host biology and celebrate the diversity of approach that comprises modern parasitological research.
Series Editors Samuel]. Black, University ofMassachusetts, Amherst, MA, US.A . J. Richard Seed, University ofNorth Carolina, Chapel Hill, NC, US.A .
AMERICAN TRYPANOSOMIASIS
edited by
Kevin M. Tyler Northwestern University - The Feinberg School of Medicine, Chicago, USA and
Michael A. Miles London School ofHygiene and Tropical Medicine London, UK
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data A c.I.P. Catalogue record for this book is available from the Library of Congress. American Trypanosomiasis Edited by Kevin M. Tyler and Michael A. Miles ISBN 978-1-4613-4837-5 ISBN 978-1-4419-9206-2 (eBook) DOI 10.1007/978-1-4419-9206-2
Copyright © 2003 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2003 Softcover reprint ofthe hardcover lst edition 2003 AII rights reserved. No part ofthis work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilm ing, record ing, or otherwise, without the written permission from the Publisher, with the exception of any material supplied specifically for the purpose ofbeing entered and executed on a computer system, for exclusive use by the purchaser of the work.
Printed on acid-free paper.
TABLE OF CONTENTS Preface
vii
The life cycle of Trypanosoma cruz; K. M. Tyler, C. L. Olson and D. M. Engman
1
Novel cell biology of Trypanosoma cruz; W. de Souza
13
Trypanosoma cruz; surface proteins A. C. C. Frasch
25
Signaling in Trypanosoma cruz; R. Docampo and S. N. J. Moreno
37
Genetic diversity of Trypanosoma cruz; O. Fernandes and B. Zingales
45
Functional disection of Trypanosoma cruz; genome: new approaches in a new era M. C. Taylor and J. M. Kelly
57
Trypanosoma cruz; cell invasion mechanisms
69
Recent developments in the pathology of Chagas disease with emphasis on the cardiovascular system H. B. Tanowitz, $ . M. Factor, J. Shirani , A. lIercil, M. Wittner, J . Scharfstein, and L. V. Kirchhoff
81
The contribution of autoimmunity to Chagas heart disease J. S. Leon and D. M. Engman
97
Trypanosoma cruz; and Chagas disease: cause and effect R. L. Tarleton
107
Specific treatment for Trypanosoma cruz; infection (Chagas disease) A. Rassi and A. O. Luquetti
117
Rational approaches to specific chemotherapy of Chagas disease
12
