Amlodipine/diltiazem/levothyroxine sodium
- PDF / 170,132 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 87 Downloads / 174 Views
1 OS
Thyrotoxicosis secondary to drug poising and hypotension: case report A 40-year-old woman developed thyrotoxicosis secondary to drug poising following an intentional overdose of levothyroxine sodium, and hypotension following overdoses of diltiazem and amlodipine in a suicide attempt. The woman was found unconscious at 5:00 am on 15 September 2019. She also showed sign of dyspnea and vomiting. She had ingested levothyroxine sodium 15000µg and unknown dose of diltiazem and amlodipine to commit suicide [dosages not stated]. She had a history of schizophrenia. At admission at 10am, her examination showed pulse rate of 75-85 beats/min and blood pressure of 83/43mm Hg. She underwent gastric lavage. Due to consistent hypotension and drowsiness, she was transferred to another hospital. Her lab tests showed elevated levels of thyroid hormones. She was diagnosed with thyrotoxicosis due to levothyroxine sodium poising. The woman underwent hemoperfusion, and she regained consciousness. She was treated with norepinephrine and pantoprazole. On the next day, 16 September 2019, the hemodynamic instability had not improved clinically. Her examination showed body temperature of 39.2°C. Toxicological examination showed diltiazem and amlodipine. She underwent plasmapheresis and was treated with metoprolol and propylthiouracil. On the third day, her blood pressure normalized; however, she still had signs of panhidrosis and fever. Laboratory tests showed improved thyroid function gradually. She was discharged on 24 September 2019 with normal thyroid function. At two weeks follow-up, she did not complain of special discomfort. Li R, et al. Plasmapheresis in the treatment of multi-drug intoxication involving levothyroxine sodium and calcium channel blockers: a case report. Annals of Palliative 803505374 Medicine 2020: 17 Sep 2020. Available from: URL: http://doi.org/10.21037/apm-20-190
0114-9954/20/1825-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 10 Oct 2020 No. 1825
Data Loading...
