Amoxicillin
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Klebsiella oxytoca haemorrhagic enterocolitis: 2 case reports Two girls developed Klebsiella oxytoca-associated haemorrhagic enterocolitis after receiving amoxicillin for Streptococcus pyogenes tonsillitis. The first girl, aged 14 years, received amoxicillin 1.5 g/day for 7 days. Four days later she was admitted to hospital with severe abdominal pain and bloody diarrhoea which had started the previous day. She had a mildly elevated WBC count (12 200 cells/µL), a small amount of gas in the small intestine, and thickening of the colonic wall. On receiving supportive care her symptoms resolved and she was discharged after 7 days. Amoxicillin-resistant K. oxytoca was isolated from her stool cultures. The second girl, aged 11 years, received amoxicillin 0.9 g/day for 10 days. Two days later she developed bloody diarrhoea and severe abdominal pain. She was prescribed cefcapene pivoxil by her family doctor but her symptoms did not improve. The next day she was admitted to hospital with severe tenderness in the left lower abdomen. Her temperature was slightly elevated (37.5°C), and she had a mildly elevated WBC count (11 200 cells/µL), a small amount of gas in the small intestine, and thickening of the colonic wall. She received supportive care and her symptoms resolved; she was discharged after 9 days. Amoxicillin-resistant K. oxytoca was isolated from her stool cultures. Shinjoh M, et al. Klebsiella oxytoca-positive, penicillin-associated hemorrhagic enterocolitis in children. Pediatrics International 52: 132-153, No. 1, Feb 2010. Available from: URL: http://dx.doi.org/10.1111/j.1442-200x.2009.02949.x 803013909 Japan
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Reactions 15 May 2010 No. 1301
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