Amphetamine-induced striatal dopamine release in schizotypal personality disorder
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ORIGINAL INVESTIGATION
Amphetamine-induced striatal dopamine release in schizotypal personality disorder Judy L. Thompson 1,2 & Daniel R. Rosell 3 & Mark Slifstein 4 & Xiaoyan Xu 5 & Ethan G. Rothstein 3,6 & Yosefa A. Modiano 3,7 & Lawrence S. Kegeles 5,8 & Harold W. Koenigsberg 3,9 & Antonia S. New 3 & Erin A. Hazlett 3,10 & Margaret M. McClure 3,11 & M. Mercedes Perez-Rodriguez 3 & Larry J. Siever 3,9,10 & Anissa Abi-Dargham 4 Received: 23 September 2019 / Accepted: 18 May 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Rationale Previous research has suggested that schizotypal personality disorder (SPD), a condition that shares clinical and cognitive features with schizophrenia, may be associated with elevated striatal dopamine functioning; however, there are no published studies of dopamine release within subregions of the striatum in SPD. Objectives To characterize dopamine release capacity in striatal subregions and its relation to clinical and cognitive features in SPD. Methods We used positron emission tomography with [11C]raclopride and an amphetamine challenge to measure dopamine D2receptor availability (binding potential, BPND), and its percent change post-amphetamine (ΔBPND) to index amphetamineinduced dopamine release, in subregions of the striatum in 16 SPD and 16 healthy control participants. SPD participants were evaluated with measures of schizotypal symptom severity and working memory. Results There were no significant group differences in BPND or ΔBPND in any striatal subregion or whole striatum. Among SPD participants, cognitive-perceptual symptoms were associated at trend level with ΔBPND in the ventral striatum, and disorganized symptoms were significantly negatively related to ΔBPND in several striatal subregions. Conclusions In contrast to previous findings, SPD was not associated with elevated striatal dopamine release. However, in SPD, there was a moderate positive association between ventral striatal dopamine release and severity of cognitive-perceptual symptoms, and negative associations between striatal dopamine release and severity of disorganized symptoms. Future larger scale investigations that allow for the separate examination of subgroups of participants based on clinical presentation will be valuable in further elucidating striatal DA functioning in SPD. Keywords Schizotypal personality disorder . Schizophrenia . PET . Dopamine . Striatum . Disorganized symptoms . Positive symptoms . Working memory Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00213-020-05561-5) contains supplementary material, which is available to authorized users. * Judy L. Thompson [email protected]
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Present address: The Graduate Center, City University of New York, New York, NY 10016, USA
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Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA
Present address: Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
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Department
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