An autonomous self-healing hydrogel with high polydopamine content for improved tensile strength
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An autonomous self-healing hydrogel with high polydopamine content for improved tensile strength Jinxin Huang1, Wei Zhang1,*, Heng Li1, Xiaogang Yu1, Shuaiwen Ding1, and Chengwei Wu1,*
1
State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China
Received: 15 April 2020
ABSTRACT
Accepted: 12 August 2020
Biocompatible polydopamine–polyacrylamide (PDA–PAM) hydrogel has good self-healing performance. However, there is a trade-off between the self-healing ability and the mechanical strength. Excellent self-healing often results in the poor mechanical strength, which limits the application in load-bearing field. Here, we successfully prepare PDA–PAM hydrogels with improved strength and good self-healing properties simultaneously. By adjusting the pH and ammonium persulfate (APS) content of the hydrogel solution to promote dopamine (DA) polymerization, PDA–PAM hydrogel with a high content of polydopamine (PDA) is developed, which demonstrates excellent self-healing properties and mechanical strength. In particular, the PDA–PAM hydrogel with high PDA content (DA/AM = 5%) has a tensile strength of 16 kPa and the tensile strength spontaneously recovers 96% in 2 h after the tensile fracture. The obtained hydrogel also displays good biocompatibility.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Introduction The significant self-healing performance provides the hydrogels with long service time, leading to cost reduction in repairing or replacing the damaged hydrogel devices [1, 2]. Self-healing hydrogels have attracted attention widely in tissue engineering [3], drug release [4] and smart electronic devices [5, 6]. According to the self-healing conditions, self-healing hydrogels can be divided into externally non-
autonomous self-healing hydrogels and autonomous self-healing hydrogels. Non-autonomous self-healing hydrogels require appropriate external stimuli, such as heat [6], pH [7], magnetic field [8] or light irradiation [9, 10], etc. to activate or accelerate the selfhealing process. However, for the hydrogel involved in vivo or installed in the finished product, the external stimulus is difficult to be applied, which will result in barriers of hydrogel self-healing [11]. Thus, how to design a hydrogel with autonomous selfhealing ability is the main focus.
Handling Editor: Annela M. Seddon.
Address correspondence to E-mail: [email protected]; [email protected]
https://doi.org/10.1007/s10853-020-05252-8
J Mater Sci
Among different design strategies, mussel-inspired polydopamine (PDA)-based hydrogels are typical examples of autonomous self-healing. These hydrogels can reconstruct hydrogel networks by synergestic effect of various interactions such as hydrogen bonds, metal-catechol coordination, p–p interactions, etc. [12–16]. Most previously reported PDA-based self-healing hydrogels are developed on metal chelation. While Han et al. [17] proposed the toxicity of metals may be an an
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