An Investigation on DNA Binding, Cleavage and Antimicrobial Properties of Mononuclear Co(II), Ni(II) and Cu(II) Complexe
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ORIGINAL ARTICLE
An Investigation on DNA Binding, Cleavage and Antimicrobial Properties of Mononuclear Co(II), Ni(II) and Cu(II) Complexes Derived from N, O Donor Schiff Bases Aveli Rambabu 1 & Nirmala Ganji 1 & Sreenu Daravath 1 & Gali Ramesh 1 & Shivaraj 1 Received: 19 June 2020 / Accepted: 24 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Two sets of mononuclear N, O-chelate complexes, 1a [Co(L1)2(H2O)2], 1b [Ni(L1)2] and 1c [Cu(L1)2], and 2a [Co(L2)2(H2O)2], 2b [Ni(L2)2] and 2c [Cu(L2)2], from respective Schiff base ligands, HL1: 2-((E)-(6-(trifluoromethoxy)phenylimino)methyl)-5methylphenol, C 15 H 12 F 3 NO 2 ) and HL 2 : 2-((E)-(4-(trifluoromethoxy)phenylimino)methyl)-4,6-dichlorophenol, C14H8Cl2F3NO2) have been synthesized and well-characterized by analytical and various spectroscopic techniques like mass spectrometry, FT-IR, UV-visible, magnetic susceptibility, ESR and thermogravimetric studies. The geometries are proposed as octahedral for complexes 1a and 2a, whereas square planar for complexes 1b, 1c, and 2b, 2c. DNA binding study was investigated against calf thymus DNA for synthesized complexes comparing with parent ligands and resulted in intercalation mode of binding which was further supported by fluorescence quenching and viscometric titrations. Nuclease efficacy was also investigated against supercoiled pBR322 DNA and a good cleavage pattern was shown by metal complexes. The complexes were found to possess good antimicrobial activity compared to free ligands against bacterial species, Bacillus amyloliquefaciens and Escherichia coli as well as fungal species, Macrophomina phaseolina and Sclerotium rolfsii. Keywords Mononuclear metal complex . DNA binding . DNA cleavage . Antimicrobial activity
Introduction For many years, the drug-DNA interaction study has been drawn the attention of many biochemists because its role remains a greater challenge at the interface of chemistry and biology [1–3]. DNA provides various potential binding sites for transition metals, such as anionic phosphate backbone, electron-rich bases, and the major or minor grooves [4]. Transition metal complexes can interact with DNA mainly in two types of binding patterns: Covalent and non-covalent binding, in which, the later one includes electrostatic interaction, intercalation, and major/minor groove binding [5–7]. So far, chemists developed a huge number of drugs of organic Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10895-020-02614-y) contains supplementary material, which is available to authorized users. * Shivaraj [email protected] 1
Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India
and inorganic compounds for the treatment of various carcinomas. Among them, the covalent cross-linker, cisplatin occupied the pride position of minimizing the cell replication thereby reducing the carcinoma. The cisplatin’s side effects led to the discovery of its analogs like carboplatin, oxaliplatin, and nedaplati
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