An isolated pig heart for the development, validation and translation of novel magnetic resonance techniques
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An isolated pig heart for the development, validation and translation of novel magnetic resonance techniques
BioMed Central
Open Access
Andreas Schuster*1, Amedeo Chiribiri1, Richard Southworth1, Masaki Ishida1, Andreas Indermühle1, Christian H Jansen1, Reza M Razavi1, Inga Grünwald2 and Eike Nagel1 Address: 1King's College London, London, UK and 2German Heart Institute, Berlin, Germany * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O17
doi:10.1186/1532-429X-12-S1-O17
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/O17 © 2010 Schuster et al; licensee BioMed Central Ltd.
Introduction Novel magnetic resonance (MR) techniques and imaging biomarkers are often validated in small animal models or empirically in patients. The direct translation of small animal cardiac MR imaging protocols to humans is rarely possible, while validation of novel imaging techniques in humans by tracking changes in MR biomarkers in response to externally controlled changes in blood flow, for example, is difficult, or unethical. An isolated bloodperfused pig heart model which closely resembles human physiology, anatomy and size, can be exquisitely controlled in terms of regional blood flow, oxygenation, afterload and workload, and can be imaged by the same equipment used for humans. It would therefore be a valuable tool for the development, validation and translation of novel magnetic resonance techniques.
Purpose To design and build a novel MR-compatible, explanted, blood-perfused and free-beating pig heart model and test its feasibility at a clinical 3 Tesla MR Scanner.
UK) under terminal anaesthesia and transported to the laboratory under cold cardioplegic arrest (STH solution). The perfusion system consists of a separate haemoperfusate and dialysate circuit. Blood temperature and oxygenation is controlled by an oxygenator with an integrated heat exchanger. We tested functional cardiac imaging (CINE), high-resolution perfusion imaging (
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