An Omics Perspective on Cancer Research
Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinfor
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William C.S. Cho Editor
An Omics Perspective on Cancer Research
Editor William C.S. Cho Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong SAR PR China
ISBN 978-90-481-2674-3 e-ISBN 978-90-481-2675-0 DOI 10.1007/978-90-481-2675-0 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009929347 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Postgenome science is characterized by omics data related to genome, transcriptome, epigenome, proteome, metabolome and interactome. In the omics era, it is a revolution in cancer research which fundamentally shifts the strategy from piece-bypiece to global analysis and from hypothesis-driven to discovery-based research. This book attempts to take a comprehensive overview on different areas of omics technologies for cancer research. It expounds important omics technologies which are multidimensional tools that may translate into clinical applications serving as the basis for personalized medicine of the 21st century. This book not only serves as an introduction to novices to the area and a useful reference for those already involved, but also serves as a stimulus to these and others to develop new approaches to cancer research. November 2009
William C.S. Cho
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Contents
1 Omics Approaches in Cancer Research................................................. William C.S. Cho
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2 Recent Advances in Cancer Genomics and Cancer-Associated Genes Discovery............................................... Bin Guan, Tian-Li Wang, and Ie-Ming Shih
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3 An Integrated Oncogenomic Approach: From Genes to Pathway Analyses.......................................................... Jeff A. Klomp, Bin T. Teh, and Kyle A. Furge
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4 The Epigenomics of Cancer.................................................................... Izuho Hatada 5 Involvement of MicroRNAs in Human Cancer: Discovery and Expression Profiling........................................................ Massimo Negrini and George A. Calin
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6 Functional Proteomics in Oncology: A Focus on Antibody Array-Based Technologies.................................. 105 Marta Sanchez-Carbayo 7 Protein Graphs in Cancer Prediction..................................................... 125 Humberto González-Díaz, Giulio Ferino, Francisco J. Prado-Prado, Santiago Vilar, Eugenio Uriarte, Alejandro Pazos, and Cristian R. Munteanu 8 The Use of Metabolomics in Cancer Research...................................... 141 B. van Ravenzwaay, G.C. Cunha, E. Fabian, M. Herold,
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