Analyses of the Fourier Transform Infrared Spectra of Pleural Mesothelioma Tissues
- PDF / 1,533,073 Bytes
- 10 Pages / 612 x 792 pts (letter) Page_size
- 52 Downloads / 156 Views
IOPHOTONICS
Analyses of the Fourier Transform Infrared Spectra of Pleural Mesothelioma Tissues Lu Qiua,*, Shengjie Yangb, Xiaohua Yanga, Wenbo Xia, Yi Zhaob, Congmin Yub, Minzhen Sic, Jianping Dud, Wei Lid, and Yun Heb a Department
of Chemistry and Life Science, Chuxiong Normal University, Chuxiong, 675000 P. R. China b Chuxiong State People Hospital, Chuxiong, 675000 P. R. China c Department of Electronic and Physical Sciences, Chuxiong Normal University, Chuxiong, 675000 P. R. China d Dayao County People Hospital, Dayao, 675400 P. R. China *e-mail: [email protected] Received March 15, 2019; revised January 10, 2020; accepted January 10, 2020
Abstract—Eleven cases of pleural mesothelioma and two cases of pleural normal tissue were detected using Fourier transform infrared spectroscopy. The differences between pleural mesothelioma and normal pleural tissues identified by comparison of their respective Fourier transform infrared spectra were as follows: (1) a higher relative intensity of the protein amide I band at 1641 cm–1 for pleural mesothelioma compared to normal pleural tissues, a pointed peak of amide II band at l550 cm–1 for pleural mesothelioma, and a higher relative intensity compared to normal pleural tissues, all relating to increased protein content in pleural mesothelioma; (2) a symmetric stretch of the vibration band of phosphodiester bonds in the nucleic acid molecules of pleural mesothelioma towards the long 1240 cm–1 wave, and a higher relative intensity compared to normal pleural tissues, indicating increased nucleic acid content of the pleural mesothelioma; (3) a lower relative intensity of the absorption peak near 2854–2922 cm–1 in the pleural mesothelioma compared to normal pleural tissue, indicating reduced lipid content of the pleural mesothelioma; (4) a lower relative intensity of the absorption peak near 1047 cm–1 associated with soluble sugar content of the pleural mesothelioma compared to normal pleural tissues. Our results show that Fourier transforms infrared spectra exists differences between pleural mesothelioma and normal pleural tissues. It is expected to become a new method for rapid identification of pleural mesothelioma. Keywords: Pleural mesothelioma, Fourier transform infrared spectra (FTIR), Protein, Nucleic acid, Lipid, Sugar DOI: 10.1134/S0030400X2008041X
INTRODUCTION Pleural mesothelioma is a malignant cancer [1] classified into limited pleural mesothelioma and diffuses pleural mesothelioma [2]. While 20% of cases occur in the parietal pleural region, 80% occur in the visceral pleural region. Malignant pleural mesothelioma is typically diagnosed in patients older than 40 years of age. It is less frequently observed in women compared to men [3]. The occurrence of pleural mesothelioma is closely related to asbestos. The incidence of pleural mesothelioma is higher in people exposed to asbestos compared to those not exposed to asbestos [4]. Pleural mesothelioma was associated with the infection of simian-virus [5], associated with the TERT gene over-expression, too [6]. Pleur
Data Loading...
