Analysis of Parallel Spike Trains
Action potentials, or spikes, are the most salient expression of neuronal processing in the active brain, and they are likely an important key to understanding the neuronal mechanisms of behavior. However, it is the group dynamics of large networks of neu
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Volume 7
Series Editors Alain Destexhe CNRS Gif-sur-Yvette France Romain Brette École Normale Supérieure Paris France
For further volumes: http://www.springer.com/series/8164
Sonja Grün Stefan Rotter Editors
Analysis of Parallel Spike Trains
Editors Sonja Grün Laboratory for Statistical Neuroscience RIKEN Brain Science Institute 2-1 Hirosawa Wakoshi Saitama 351-0198 Japan [email protected]
Stefan Rotter Bernstein Center Freiburg & Faculty of Biology Albert-Ludwig University Hansastrasse 9a 79104 Freiburg Germany [email protected]
ISBN 978-1-4419-5674-3 e-ISBN 978-1-4419-5675-0 DOI 10.1007/978-1-4419-5675-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010933856 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Cover design: The cover artwork (original in oil pastel and acrylic) was designed and created by Adrián Ponce Alvarez. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Close to fifty years ago, when two generations of neuroscientists contributing to this book had not yet been born and I was still happy in high school, George Gerstein, Donald Perkel, and colleagues, in a series of papers, laid the foundations for what was to become the quantitative analysis of the dynamics of neuronal spiking activity and the interactions within and across neuronal networks. In the context of the present textbook, it is instructive to reread some of these papers. The full abstract of the 1960 Science paper (Gerstein 1960) reads: The use of a high-speed digital computer for investigation of neural firing patterns is described. The high sensitivity of the method permits detection of stimulus-response relations buried in a background of spontaneous activity.
The abstract of the 1964 Science paper (Gerstein and Clark 1964) continues: A tungsten microelectrode with several small holes burnt in the vinyl insulation enables the action potentials from several adjacent neurons to be observed simultaneously. A digital computer is used to separate the contributions of each neuron by examining and classifying the waveforms of the action potentials. These methods allow studies to be made of interactions between neurons that lie close together.
Such studies were indeed made, albeit that their number
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