Analysis of pathological changes and related factors in liver tissue of HBeAg-negative patients with low HBsAg levels
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ORIGINAL ARTICLE
Analysis of pathological changes and related factors in liver tissue of HBeAg‑negative patients with low HBsAg levels Li Liu1 · Chunyun Liu1 · Junyi Li1 · Yingrong Du1 · Jie Chen1 · Hui Wang1 · Huimin Li1 · Lixian Chang1 Received: 30 December 2019 / Accepted: 4 July 2020 © Springer Nature Switzerland AG 2020
Abstract The relationship between pathological changes in liver tissue and the level of hepatitis B surface antigen (HBsAg) remains unclear. This study aimed to analyze the pathological changes in liver tissue and its related factors in patients with low-level HBsAg in order to provide a basis for judging the condition of these patients. A retrospective study was performed on 96 chronic hepatitis B patients with HBsAg levels 0.05 IU/ml. The histopathological examination of these patients was conducted. Univariate and multivariate analyses were used to determine risk factors for pathological changes. Among the 96 patients, 57.3% (55) had inflammatory events ≥ G2 and 33.4% (33) had fibrosis ≥ S2. HBV infection duration (p = 0.001) and splenic vein diameter (p = 0.001) were independent risk factors of liver inflammation (≥ G2) in patients with low-level HBsAg, while AST (p = 0.006) and PLT (p = 0.005) were independent risk factors of liver fibrosis (≥ S2). Moreover, HBV infection duration (p
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