Analysis of PDMS based MEMS device for drug delivery systems
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TECHNICAL PAPER
Analysis of PDMS based MEMS device for drug delivery systems K. Srinivasa Rao1 • G. V. Ganesh1 • G. Sai Lakshmi1 • Ch. Gopichand1 • K. Grija Sravani1,2 Received: 6 February 2020 / Accepted: 5 September 2020 Ó Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract This is paper briefly explains the MEMS based piezoelectrically actuated micropump and its applications for the drug delivery system. The micropump is designed and it consists of four elements like electrodes, piezoelectric layer, flexible membrane and a reservoir. It is analyzed for three different materials like PZT-5H, PZT-5A and BaTiO3. Among them BaTiO3 is used as piezoelectric material. By using the FEM tool COMSOL Multiphysics, mechanical behavior of the micropump is evaluated as flow velocity and flow rate of 8.92 m/s and 0.854 ml/min at 50 V respectively. The obtained flow rate for the micropump is best suitable in cardio-vascular, hypertension cases where the drug need to be delivered with an appropriate flow rate.
1 Introduction MEMS technology is one of the most emerging technologies of the twenty-first century and has the potential to create tiny integrated circuits. These devices have gained more interest because of their miniature size, high performance, low response time and ability to consume less power (Ashraf et al. 2011). MEMS devices have expanded to various domains like bio-medical applications, radiofrequency operation switches, biosensors etc. These devices include various applications like navigation sensors, disk drive heads, blood pressure sensor, fiber-optic network components, and munitions guidance. Among them, Drug delivery system is one the revolutionary application of MEMS which replaces the conventional drug delivery systems efficiently. Delivery of drug into the patient’s body plays a predominant role in medical science. Action of drug is beneficial only when it is delivered within a certain range, beyond the range creates toxic effects whereas beneath the range, the performance is negligible (Srinivasa Rao et al. 2018). Prior to the invention of MEMS based drug delivery system various drug delivery developments were
& K. Srinivasa Rao [email protected] 1
Department of ECE, MEMS Research Center, KL University, Green Fields, Vaddeswaram, Guntur 522502, India
2
Department of ECE, National Institute of Technology, Silchar, Assam, India
performed. Basic drug delivery process consists of oral medication using capsules (Guha et al. 2018). Even though the drug is sent into body in fixed proportions, there is no assurance that the drug will be carried to the specific part in definite proportions. Also, some drugs cannot survive the inner gastral environment which is mostly acidic is a point to be considered (Sateesh and Rao 2017). Improvisations to this process, parental injections were implemented where drug is directly injected into the patient’s body (Srinivasa Rao et al. 2020; Jithendra Prasad and Shameem 2016). Even though the time tak
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