Chitosan-Based Ocular Drug Delivery Systems
Chitosan is widely used in ocular drug delivery systems due to its biocompatibility, biodegradability, and favorable physicochemical characteristics. Chitosan-based ocular drug delivery systems are widely reported to improve the bioavailability at the ant
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Functional Chitosan Drug Delivery and Biomedical Applications
Functional Chitosan
Sougata Jana • Subrata Jana Editors
Functional Chitosan Drug Delivery and Biomedical Applications
Editors Sougata Jana Department of Pharmaceutics Gupta College of Technological Sciences Asansol, West Bengal, India
Subrata Jana Department of Chemistry Indira Gandhi National Tribal University Amarkantak, Madhya Pradesh, India
Department of Health and Family Welfare Directorate of Health Services Kolkata, India
ISBN 978-981-15-0262-0 ISBN 978-981-15-0263-7 https://doi.org/10.1007/978-981-15-0263-7
(eBook)
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Preface
The book focuses on functional chitosan for the purpose of drug delivery and biomedical applications. Chitosan is composed of α-1, 4-linked 2-amino-2deoxy-α-d-glucose (N-acetyl glucosamine). It is a nontoxic, biodegradable, biocompatible natural amino polysaccharide with versatile applications. According to the United States Food and Drug Administration (USFDA), it is a GRAS (Generally Recognized as Safe) material and, hence, is widely used in pharmaceutical and biomedical fields, including drug delivery, food technology, and tissue engineering. It has a cationic character owing to its primary amino groups (-NH2). These primary amino groups are important for synthetic modifications for controlled drug release, in situ gelation, mucoadhesion, permeation enhancement, and transfection properties. Due to its chemical modifications, most of these characteristics can even be further improved. Due to its fast dissolution in gastric fluid, its use is limited as oral sustained drug release
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