Analysis of risk factors for progressive fibrovascular proliferation in proliferative diabetic retinopathy
- PDF / 341,071 Bytes
- 8 Pages / 547.087 x 737.008 pts Page_size
- 96 Downloads / 164 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL PAPER
Analysis of risk factors for progressive fibrovascular proliferation in proliferative diabetic retinopathy Yu-Bo Wu . Chen-Guang Wang . Ling-Xian Xu . Chen Chen . Xue-Bin Zhou . Guan-Fang Su
Received: 18 January 2020 / Accepted: 15 May 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To investigate the risk factors associated with progressive fibrovascular proliferation (FVP) in proliferative diabetic retinopathy (PDR). Methods We retrospectively reviewed the clinical data of patients who underwent pars plana vitrectomy for PDR between August 2017 and October 2019 at our department of ophthalmology. The FVP was divided into five grades based on the coverage area of proliferative membrane. Then we compared the patients with different severities of FVP to analyze the risk factors for higher grade of FVP in PDR. Results Univariate analysis showed that positive urinary protein (p = 0.007), higher levels of serum blood urea nitrogen (BUN) (p \ 0.001) and serum creatinine (p \ 0.001), more severe stage of estimated glomerular filtration rate (p \ 0.001), age \ 45 years (p = 0.005), longer duration of diabetic retinopathy (p = 0.007), history of hypertension (p = 0.034) and smoking (p = 0.008) were related to FVP grade C 3. Multivariate analysis showed that the level of BUN, age \ 45 years and smoking were independent risk factors for FVP grade C 3 in PDR patients.
Y.-B. Wu C.-G. Wang L.-X. Xu C. Chen X.-B. Zhou G.-F. Su (&) Department of Ophthalmology, Second Hospital of Jilin University, Jilin University, No. 218, ChangChun, Ziqiang Street, Changchun 130041, People’s Republic of China e-mail: [email protected]
Conclusion This study demonstrated that BUN (odds ratio [OR] = 1.318, 95% confidence interval [CI] = 1.150–1.511, p \ 0.001), age B 45 years (OR = 3.774, 95% CI = 1.762–8.082, p = 0.001) and smoking (OR = 2.111, 95% CI = 1.040–4.288, p = 0.039) were independent risk factors for progressive FVP in PDR among northeastern Chinese patients. Keywords Diabetes Proliferative diabetic retinopathy Fibrovascular proliferation
Introduction The global incidence of diabetes mellitus (DM) is predicted to reach 700 million in 2045 [1]. China has the largest DM population in the world (more than 1 billion), leading to enormous socioeconomic burden on the patients and society [2]. Diabetic retinopathy (DR) is one of the main microvascular complications of DM. It is among the commonest causes of visual impairment and blindness in the working-age group [1]. DR can be divided into non-proliferative and proliferative stages. Compared with non-proliferative DR, proliferative diabetic retinopathy (PDR) manifests as neovascularization, which gradually leads to vitreous hemorrhage (VH), fibrovascular proliferation (FVP) and eventual tractional retinal detachment
123
Int Ophthalmol
(TRD) [3]. Early studies confirmed that hemoglobin A1c (HbA1c) concentration, duration of DM, body mass index (BMI), blood pressure, kidney function, etc., were associated with
Data Loading...
