Angiogenesis-Based Dermatology
This book covers in detail all aspects of angiogenesis in dermatology. Angiogenesis is a principle that can be used to guide treatment of diseases of any organ system. Dermatologists already inhibit angiogenesis as part of their treatment of multiple comm
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AngiogenesisBased Dermatology
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Angiogenesis-Based Dermatology
Jack L. Arbiser Editor
Angiogenesis-Based Dermatology
Editor Jack L. Arbiser Emory University School of Medicine Atlanta, GA USA
ISBN 978-1-4471-7312-0 ISBN 978-1-4471-7314-4 (eBook) DOI 10.1007/978-1-4471-7314-4 Library of Congress Control Number: 2017933481 © Springer-Verlag London Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer-Verlag London Ltd. The registered company address is: 236 Gray’s Inn Road, London WC1X 8HB, United Kingdom
Preface
This book is dedicated to the memory of Judah Folkman, MD, with whom I had the pleasure of spending a 4-year postdoctoral fellowship, between the years 1994 and 1998. There are several aspects to Dr. Folkman’s personality that made him so effective in advancing angiogenesis in medicine. First, his research was clinically driven. He wanted to use angiogenesis as a tool to cure human disease. Thus, he chose to use basic research to address clinical problems, not as an end to itself. There are two camps of people who perform basic research with regard to human disease. The first believes that we have to know everything in order to treat human disease. A corollary of that belief is that once we know everything, we will be able to design a specific targeted therapy that cures advanced cancer or other ailment, with no side effects. This will be accomplished because advanced cancers are addicted to an oncogene, and targeting that oncogene will lead to a painless cure. The second camp is the one that Dr. Folkman belonged to, in that he wanted to know how we could leverage the knowledge that we have today to help patients who are sick today. As a pediatric surgeon, he recognized that patients who are sick today need treatments today, and will likely not survive until that utopian time that we have magic bullets with no side effects. His conce
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