Angiogenesis in Wound Healing following Pharmacological and Toxicological Exposures

  • PDF / 841,760 Bytes
  • 11 Pages / 595.276 x 790.866 pts Page_size
  • 100 Downloads / 149 Views

DOWNLOAD

REPORT


WOUND HEALING AND TISSUE REPAIR (C YATES AND R MOTA, SECTION EDITORS)

Angiogenesis in Wound Healing following Pharmacological and Toxicological Exposures Russell Hunter 1 & Katie T. Kivlighan 2 & Sharon Ruyak 2 & Quiteria Jacquez 2 & Katherine E. Zychowski 2

# Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract Purpose of Review Toxicological and pharmacological exposures may accelerate or impede wound healing and tissue repair. These exposures impact the wound healing cascade and steps within the process including (1) hemostasis, (2) the inflammatory stage, (3) proliferation, and (4) maturation. Angiogenesis plays a critical role during the wound healing process via clot invasion and organization of vasculature throughout new connective tissue. This review examines how toxicological insults and pharmacotherapeutics impact the tissue healing process. We focus on four primary environmental exposures, namely, radiation, pharmacotherapeutics, metals, and dioxins for the scope of this review. Recent Findings Recent literature suggests that individuals with comorbidities such as autoimmune disorders or cardiometabolic diseases are most susceptible to angiogenic delays and wound healing deficits following toxicological or pharmacological insult. As newer drug-delivery systems and pharmaceutics become available, exposures to these compounds have led to improved wound healing by impacting molecular angiogenic pathways. Environmental and medical exposures from radiological or persistent pollutants may impede wound healing via these angiogenic factors. Summary These data suggest that environmental exposures via metals, dioxins, exogenous radiation, or pharmaceutics will ultimately promote or diminish molecular angiogenic factors, such as vascular endothelial growth factor (VEGF), and impact the wound healing cascade. Keywords radiation . VEGF . metals . toxicology . growth factors

Introduction This article is part of the Topical Collection on Wound Healing and Tissue Repair * Katherine E. Zychowski [email protected] Russell Hunter [email protected] Katie T. Kivlighan [email protected] Sharon Ruyak [email protected] Quiteria Jacquez [email protected] 1

Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, Albuquerque, NM 87131, USA

2

College of Nursing, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM 87131, USA

There are four distinct stages of wound healing and tissue repair including hemostasis, the defensive/inflammatory phase, the proliferative phase, and the maturation phase [1]. Toxicological and pharmacological exposures target or activate different signaling molecules throughout these processes, which in turn influence angiogenesis in the wound healing process [2]. Angiogenesis involves the development of capillary sprouts, which degrade endothelial cells and invade the extracellular matrix stroma after penetration of the vascular basement membrane. This ultimately impacts endothelial cell prolifer