Animal Toxins Facts and Protocols
It is now something of a truism to say that natural toxins form a major compo nent of the molecular tools used increasingly frequently by the ever growing number of laboratories of various kinds. Evidence for this is provided not only by the increasing n
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Animal Toxins Facts and Protocols
Editedby Herve Rochat Marie-France Martin -Eauclaire
Springer Basel AG
Editors Professor Dr. Herve Rochat Laboratoire de Biochimie Faculte de Medecine Bld Pierre Dramard F-13916 Marseille Cedex 20 France
Dr. Marie-France Martin-Eauclaire Laboratoire de Biochimie FacuIte de Medecine Bld Pierre Dramard F-13916 Marseille Cedex 20 France
A CIP catalogue record for this book is available from the library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data Animal toXÎns : facts and protocols / ed. by Herve Rochat ; Marie-France Martin-Eauclaire. - Basel; Boston; Berlin: Birkhiiuser, 2000 (Methods and tools in biosciences and medicine)
ISBN 978-3-7643-6020-7 ISBN 978-3-0348-8466-2 (eBook) DOI 10.1007/978-3-0348-8466-2
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources ofreference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. AlI rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind ofuse permission ofthe copyright owner must be obtained. © 2000 Springer Basel AG Originally published by Birkhauser Verlag in 2000
Printed on acid-free paper produced from chlorine-free pulp. TCF Cover Illustration: Aah II molecule (page 175)
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Contents Ust of Contributors
VII
Abbreviations
X
Preface
XI
1. Assays for Dinoflagellate Toxins, Specifically Brevetoxin, Ciguatoxin, and Saxitoxin V.L. Trainer and M.A. Poli 2. Maitotoxin, Okadaic Acid and Microcystins: Toxins That Disturb Signal Transduction and Phosphorylations S. Puiseux-Dao, N. Boualcha and G. Diogene 3. Sea Anemone Toxins Acting on Na+ Channels and K+ Channels: Isolation and Characterization L. Beress, T. Bruhn, J. Sanchez-Rodriguez, E. Wachter and H. Schweitz 4. Nemertine Toxins W.R.Kem
1
20
31
57
5. Conus Peptides and their Iodinated Derivatives as Probes for
Ion Channels and Receptors L.J. Cruz, J.M. McIntosh, J.S. Imperial and W.R. Gray
74
6. Ant Polypeptide Toxins K.A. Pluzhnikov, L.V. Shevchenko and E.V. Grishin
90
7. Wasp Kinins and Kinin Analogues T. Piek
99
8. Mastoparan as a G Protein Activator T. Nakajima, K. Wakamatsu and H. Mukai
116
9. Pharmacologically Active Peptides and Proteins from Bee Venom _ 127 P.N. Strong and J.D.F. Wadsworth 10. Purification and Characterization of Scorpion Toxins Acting on Voltage-Sensitive Na+ Channels M.-F. Martin-Eauclaire and H. Rochat
152
11. Immunological Properties of Scorpion Toxins C. Devaux and M. EI Ayeb
169
12. Scorpion Toxins and Pot
