Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (

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Taotao Zou

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

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Taotao Zou

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents Doctoral Thesis accepted by The University of Hong Kong, Hong Kong, China

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Supervisor Prof. Chi-Ming Che Department of Chemistry The University of Hong Kong Hong Kong China

Author Dr. Taotao Zou Department of Chemistry The University of Hong Kong Hong Kong China

ISSN 2190-5053 Springer Theses ISBN 978-981-10-0656-2 DOI 10.1007/978-981-10-0657-9

ISSN 2190-5061

(electronic)

ISBN 978-981-10-0657-9

(eBook)

Library of Congress Control Number: 2016932333 © Springer Science+Business Media Singapore 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrat