Anti-inflammatory Effects of Sanguisorbae Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice
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ORIGINAL ARTICLE Anti-inflammatory Effects of Sanguisorbae Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice Suzy Jo1, Junghyun Ryu1, Hanna Kim1, Miyoung Kim1, Mi Heon Ryu2, Hyungwoo Kim1, and Su-In Cho1 Objective:: To investigate the anti-inflammatory effects of Sanguisorbae Radix on contact dermatitis ABSTRACT Objective Methods:: Mice were sensitized by painting 30 μL of 1-fluoro-2,4-dinitrofluorobenzene (DNFB) onto each ear (CD). Methods for 3 days. Four days later, mice were challenged by painting with 50 μL of DNFB onto the shaved dorsum every 2 days. Sanguisorbae Radix methanol extract (MESR) was applied onto the shaved dorsum every 2 days. The effects of MESR on skin thickness, skin weights, histopathological changes, skin lesions and cytokine production in DNFB-induced CD mice were investigated, as well as its effects on body weights and spleen/body weight ratio. Results:: Topical application of MESR effectively inhibited enlargement of skin thickness and weight (P
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