Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature re
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REVIEW
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review Shiva Sharifzadeh 1 & Amir Hooshang Mohammadpour 1,2 & Ashraf Tavanaee 3 & Sepideh Elyasi 1 Received: 10 December 2019 / Accepted: 18 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were “DRESS syndrome,” “drug-induced hypersensitivity syndrome (DIHS),” “antibiotics,” “antimicrobial,” and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS. Keywords DRESS syndrome . Drug-induced hypersensitivity syndrome (DIHS) . Antibiotics . Antimicrobial agents
Introduction Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), and DIDMOHS (drug-induced delayed multiElectronic supplementary material The online version of this article (https://doi.org/10.1007/s00228-020-03005-9) contains supplementary material, which is available to authorized users. * Sepideh Elyasi [email protected] 1
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran
2
Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3
Department of Infectious Disease, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
organ hypersensitivity syndrome) [1], is a delayed potentially fatal multi-organ systemic idiosyncratic drug reaction [2, 3]. The preval
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