Antiepileptic Drug Discovery Novel Approaches
This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches f
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Alan Talevi Luisa Rocha Editors
Antiepileptic Drug Discovery Novel Approaches
METHODS AND
IN
P H A R M ACO LO G Y
T OX I CO LO G Y
Series Editor Y. James Kang University of Louisville School of Medicine Prospect, Kentucky, USA
For further volumes: http://www.springer.com/series/7653
Antiepileptic Drug Discovery Novel Approaches
Edited by
Alan Talevi CONICET, National University of La Plata, La Plata, Argentina
Luisa Rocha Department of Pharmacobiology, Center for Research and Advanced Studies, Mexico City, Mexico
Editors Alan Talevi Laboratorio de Investigación y Desarrollo de Bioactivos (LIDeB) Faculty of Exact Sciences National University of La Plata La Plata, Buenos Aires, Argentina
Luisa Rocha Department of Pharmacobiology Center for Research and Advanced Studies Mexico City, Mexico
ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-4939-6353-9 ISBN 978-1-4939-6355-3 (eBook) DOI 10.1007/978-1-4939-6355-3 Library of Congress Control Number: 2016949635 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Despite the introduction of several novel antiepileptic medications to the clinical practice during the last 20 years, the proportion of patients failing to achieve a seizure-free status has not improved substantially. Furthermore, current antiepileptic drugs provide symptomatic control to responsive patients (anticonvulsive or antiseizure effect) but have not proven to prevent the setting and progression of the disorder (antiepileptogenesis). Leading experts have emphasized the need for paradigm shifts in the field of antiepileptic drug discovery as a key factor to arrive at truly innovative therapeutic solutions. Such innovative solutions involve a wide and multidisciplinary array of strategies, including, a
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