Antiepileptic Drug Interactions A Clinical Guide
This updated third edition of a successful book is a description of both pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, including details of the magnitude and mechanism of interactions, and also of drug combinations t
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Antiepileptic Drug Interactions A Clinical Guide Third Edition
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Antiepileptic Drug Interactions
Philip N. Patsalos
Antiepileptic Drug Interactions A Clinical Guide Third Edition
Philip N. Patsalos Therapeutic Drug Monitoring Unit Department of Clinical and Experimental Epilepsy UCL-Institute of Neurology Queen Square London UK Chalfont Centre for Epilepsy Chalfont St Peter Buckinghamshire UK
ISBN 978-3-319-32908-6 ISBN 978-3-319-32909-3 DOI 10.1007/978-3-319-32909-3
(eBook)
Library of Congress Control Number: 2016945034 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
The second edition of this book, published in June 2013, included 27 antiepileptic drugs (AEDs). Since then, two new AEDs have been licensed for clinical use (perampanel and brivaracetam), and there has been a surge of publications reporting on interactions, particularly interactions involving the newer AEDs. In this third edition, a total of 29 AEDs are reviewed, in alphabetical order, including AEDs that are not necessarily licensed worldwide but that are prescribed to patients in different countries (e.g., acetazolamide, methsuximide, piracetam, and sulthiame). AED interactions present a major challenge in the management of epilepsy, and even though our understanding of these interactions has increased substantially, the sheer size of available data has discouraged many physicians from taking an effective approach to minimize adverse consequences, which may result from these interactions. The purpose of this book is to provide in a systematic fashion a description of the drug interactions that occur between AEDs and between AEDs and nonAEDs, which may present problems for patients and that often require a drug dose adjustment. With this information, it is anticipated that medical
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