Antigens of the Major Histocompatibility Complex (HLA Antigens)
The HLA (=’ Human Leucocyte antigen locus A’) antigens are transmitted by a group of genes representing the Major Histocompatibility Complex (= MHC) of humans.
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Springer-Verlag Wien G m b H
Dr. Helmut Schenkel-Brunner Institut für Medizinische Biochemie Universität Wien, Vienna, Austria
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. © 1995 and 2000 Springer-Verlag Wien Originally published by Springer-Verlag/Wien in 2000 Softcover reprint of the hardcover 2nd edition 1995 and 2000 Editorial Consultant: Alexandra Salvini-Plawen Camera-ready copies provided by the author Printed by Druckerei Theiss GmbH, A-9400 Wolfsberg Graphic design: Ecke Bonk Printed on acid-free and chlorine-free bleached paper SPIN 10764127 Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
With 173 Figures
ISBN 978-3-7091-7244-5 ISBN 978-3-7091-6294-1 (eBook) DOI 10.1007/978-3-7091-6294-1
Foreword
As President and organiser of the 26th Congress of the International Society pf Blood Transfusion 'ISBT 2000', I am pleased to introduce this work on the biochemistry of human blood groups, which will serve as a valuable complement to blood group serology work. For this new edition the author has singlehandedly covered virtually all blood group research published before the current year. It is my firm belief that all participants in the ISBT conference will find this book a highly useful addition to their scientific libraries.
Vienna, April 2000
W.R. Mayr Congress President
Preface This revised and updated edition of the monograph on the chemistry and biochemistry of human blood groups is being published to honour the 1Oath anniversary of Dr. Karl Landsteiner's discovery of human blood groups here in Vienna. Five years have passed since publication of the first edition, and in this time research on the biochemistry of human blood groups has reached staggering proportions. Thanks to extensive molecular biological applications, research groups have identified the bearer molecules of even more blood groups, and are now able to clarify the molecular basis of a vast number of blood group specificities. Human blood group research has become one of the most fruitful of all biochemical research fields. While this development is immensely gratifying to a researcher like myself, who has worked in human blood groups for the past 34 years, coping with the close to overwhelming number of publications has proved a highly challenging task. In order to keep the number of pages of this edition from reaching a condition close to critical mass, my cr
