Antimicrobial Resistance and Implications for the Twenty-First Century
This new volume of the Emerging Infectious Diseases of the 21st Century series is a collection of chapters by leading world authorities on antimicrobial resistance of common, important bacterial, viral and fungal pathogens. This unique book should be in t
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Emerging Infectious Diseases of the 21st Century Series Editor: I. W. Fong Professor of Medicine, University of Toronto Infectious Diseases, St. Michael’s Hospital Recent volumes in this series: MALARIA: GENETIC AND EVOLUTIONARY ASPECTS Edited by Krishna R. Dronamraju and Paolo Arese INFECTIONS AND THE CARDIOVASCULAR SYSTEM: New Perspectives Edited by I. W. Fong REEMERGENCE OF ESTABLISHED PATHOGENS IN THE 21ST CENTURY Edited by I. W. Fong and Karl Drlica BIOTERRORISM AND INFECTIOUS AGENTS: A New Dilemma for the 21st Century Edited by I.W. Fong and Ken Alibek MOLECULAR PARADIGMS OF INFECTIOUS DISEASE: A Bacterial Perspective Edited by Cheryl A. Nickerson and Michael J. Schurr NEW AND EVOLVING INFECTIONS OF THE 21ST CENTURY Edited by I.W. Fong and Ken Alibek ANTIMICROBIAL RESISTANCE AND IMPLICATIONS FOR THE 21ST CENTURY Edited by I.W. Fong and Karl Drlica
A Continuation Order plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
I. W. Fong · Karl Drlica Editors
Antimicrobial Resistance and Implications for the Twenty-First Century
Karl Drlica International Center for Public Health 225 Warren Street Newark, NJ 07103-3535 USA [email protected]
I. W. Fong Director, Infectious Disease St. Michael’s Hospital 30 Bond St., Suite 4179 Cardinal Carter Wing Toronto, Ontario M5B 1W8 Canada [email protected]
ISBN: 978-0-387-72417-1
e-ISBN: 978-0-387-72418-8
Library of Congress Control Number: 2007930198 c 2008 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper. 9 8 7 6 5 4 3 2 1 springer.com
Preface
For many years after the discovery of antibiotics, microbial resistance was largely ignored. Now, however, the prevalence of antibiotic-resistant microorganisms, both in the community and in hospitals, has reached a level that impacts treatment efficacy. New, more potent agents have been introduced, but resistant microbes continue to be selectively enriched. Unfortunately, the problem of drug-resistant microorganisms extends beyond bacteria: it is also of major concern with the management of viral diseases, such as that caused by Human Immunodeficiency Virus, and with parasitic diseases such as malaria. Meanwhile, it is
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