Antiplatelet and Anticoagulation Therapy
Aspirin has been in clinical use for over 100 years, making it one of the oldest commonly used drugs in medicine, and is now predominantly used as an antiplatelet agent. Major new antiplatelet drug classes have recently become available for the clinician
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Albert Ferro • David A. Garcia Editors
Antiplatelet and Anticoagulation Therapy
Editors Albert Ferro King’s College London London UK
David A. Garcia University of New Mexico Albuquerque New Mexico USA
ISBN 978-1-4471-4296-6
ISBN 978-1-4471-4297-3 (eBook) DOI 10.1007/978-1-4471-4297-3 Springer London Heidelberg New York Dordrecht
Library of Congress Control Number: 2012950008 © Springer-Verlag London 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Drugs used to prevent and treat thrombotic diseases are amongst the most widely used in clinical medicine. Aspirin, once used principally for its anti-inflammatory and analgesic actions, is now predominantly used as an anti-platelet agent. Despite the fact that it was one of the first drugs to come into common usage, having been developed by Felix Hoffmann in 1897 and subsequently marketed by Bayer, aspirin remains the most widely used drug in the world. Warfarin was originally developed and used as a rodenticide, and in 1954 was approved for medical use in humans; since then, warfarin and related coumarin derivatives have been the only orally active anticoagulant drugs available to the physician. For decades, therefore, aspirin has dominated the antiplatelet landscape, and the vitamin K antagonists
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